COL5A1 and COL5A3

Number of citations: 0 (PubMedID 7346227)
Data Source: HPRD (in vivo)

		COL5A1	COL5A3
Name		collagen type V alpha 1 chain	collagen type V alpha 3 chain
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type V Trimer Collagen Type XI Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Collagen Trimer Collagen Type V Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Extracellular Matrix Structural Constituent Collagen Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Proteoglycan Binding
	Biological Process	Blood Vessel Development Heart Morphogenesis Cell Adhesion Cell Migration Collagen Fibril Organization Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Supramolecular Fiber Organization Negative Regulation Of Endodermal Cell Differentiation	Cell-matrix Adhesion Collagen Fibril Organization Skin Development
Pathways		Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Attachment of bacteria to epithelial cells Developmental Lineage of Pancreatic Ductal Cells	Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Attachment of bacteria to epithelial cells Developmental Lineage of Pancreatic Ductal Cells
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)	None
GWAS		Blood pressure ( 24954895 ) Central corneal thickness ( 20719862 22814818 23493294 32528159 28171582 31798171 29760442 30894546 ) Corneal structure ( 23291589 ) Crohn's disease (need for surgery) ( 23665963 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Longevity ( 20834067 ) Metabolite levels ( 23823483 ) Phosphatidylcholine levels ( 31551469 ) Refractive error ( 32231278 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1	2 interacting genes: COL1A2 COL5A1
Entrez ID		1289	50509
HPRD ID		00368	00369
Ensembl ID		ENSG00000130635	ENSG00000080573
Uniprot IDs		B2ZZ86 P20908 Q59EE7	P25940
PDB IDs		7Y37	Not available
GO Terms Enriched among Interactors		Extracellular Matrix Collagen Binding Platelet Alpha Granule Lumen Golgi Lumen Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Extracellular Matrix Binding Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Extracellular Region Extracellular Space Regulation Of Endothelial Cell Migration Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Autophosphorylation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation Negative Regulation Of Multicellular Organismal Process Platelet-derived Growth Factor Binding Cell Surface Regulation Of Glomerular Mesangial Cell Proliferation Endoplasmic Reticulum Lumen Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Autophosphorylation Proteoglycan Binding Platelet-derived Growth Factor Receptor Binding Extracellular Matrix Structural Constituent Positive Regulation Of Endothelial Cell Migration Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Platelet Activation Platelet Alpha Granule Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Regulation Of Wound Healing Regulation Of Anatomical Structure Morphogenesis Regulation Of Endothelial Cell Proliferation Growth Factor Activity Regulation Of Developmental Process Negative Regulation Of Developmental Process Regulation Of Cell Migration Regulation Of Response To Wounding Regulation Of Cell Motility Regulation Of Locomotion Response To Wounding Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Phospholipid Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Metabolic Process Collagen Fibril Organization Collagen Trimer Extracellular Matrix Structural Constituent Blood Vessel Development Protein Heterotrimerization Integrin Biosynthetic Process Extracellular Structure Organization Extracellular Matrix Organization Collagen Type I Trimer Endoplasmic Reticulum Lumen Collagen Type V Trimer Negative Regulation Of Endodermal Cell Differentiation Tendon Development Extracellular Matrix Collagen Type XI Trimer Animal Organ Morphogenesis Skin Morphogenesis Collagen Biosynthetic Process Proteoglycan Binding Tissue Development Wound Healing, Spreading Of Epidermal Cells Protein Trimerization Protein Heterooligomerization Extracellular Matrix Assembly Wound Healing, Spreading Of Cells SMAD Binding Skin Development Bone Mineralization Animal Organ Development Heart Morphogenesis Anatomical Structure Morphogenesis Eye Morphogenesis Rho Protein Signal Transduction Connective Tissue Development Sensory Organ Morphogenesis Cellular Response To Amino Acid Stimulus Biomineral Tissue Development Basement Membrane Odontogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Protease Binding Response To Amino Acid Extracellular Region Integrin Binding Heparin Binding Regulation Of Blood Pressure