COL4A3 and SERPINE2

Number of citations: 0 (PubMedID 8006028)
Data Source: HPRD (in vivo)

		COL4A3	SERPINE2
Name		collagen type IV alpha 3 chain	serpin family E member 2
Structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Extracellular Space Cytosol Extracellular Matrix Platelet Alpha Granule Neuromuscular Junction Extracellular Vesicle
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength	Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Peptidase Inhibitor Activity
	Biological Process	Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation	Nervous System Development Blood Coagulation Negative Regulation Of Cell Population Proliferation Response To Wounding Negative Regulation Of Platelet Activation Negative Regulation Of Plasminogen Activation Negative Regulation Of Sodium Ion Transport Negative Regulation Of Protein Processing Cerebellar Granular Layer Morphogenesis Cell Differentiation Protein Catabolic Process Platelet Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Cell Migration Secretion By Cell Secretory Granule Organization Negative Regulation Of Protein Catabolic Process Mating Plug Formation Negative Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Positive Regulation Of Astrocyte Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Innervation Seminal Vesicle Epithelium Development Negative Regulation Of Platelet Aggregation
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Dissolution of Fibrin Clot
Diseases		Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome	None
GWAS		Advanced age-related macular degeneration ( 26691988 ) Central corneal thickness ( 29760442 31798171 32528159 ) Corneal structure ( 23291589 ) Diabetic nephropathy in type 1 diabetes ( 31537649 ) Hematuria ( 30476138 ) Hematuria (moderate to severe) ( 30476138 ) Intraocular pressure ( 29235454 ) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649 ) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649 ) Macroalbuminuria in type 1 diabetes ( 31537649 ) Macular thickness ( 30535121 ) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000 ) Refractive error ( 32231278 ) Resting heart rate ( 27798624 )	Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) ( 23648065 ) Blood protein levels ( 30072576 ) Cerebrospinal T-tau levels ( 28247064 ) Cytokine levels ( 31679650 ) Cytokine network levels (multivariate analysis) ( 31679650 ) Height ( 20881960 31562340 ) Inflammatory biomarkers (multivariate analysis) ( 33110245 ) Mean platelet volume ( 27863252 32888494 ) Platelet-derived growth factor BB levels ( 27989323 )
Interacting Genes		17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A	9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ETS2 F2 FAM9B
Entrez ID		1285	5270
HPRD ID		00354	01510
Ensembl ID		ENSG00000169031	ENSG00000135919
Uniprot IDs		Q01955	P07093
PDB IDs		5NB0 6WKU	4DY0 4DY7
GO Terms Enriched among Interactors		Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Collagen Binding Glycosaminoglycan Binding Basement Membrane Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heparin Binding Peptidase Activator Activity Extracellular Space Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Platelet Alpha Granule High-density Lipoprotein Particle Regulation Of Cell Migration Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Motility Integrin Binding Regulation Of Locomotion Positive Regulation Of Synaptic Transmission Regulation Of Cell Differentiation Amyloid-beta Complex Signaling Receptor Binding Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Inflammatory Response Regulation Of Multicellular Organismal Process Dendrite Development Identical Protein Binding Regulation Of Cell Adhesion Acute-phase Response Endodermal Cell Differentiation Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development Intermembrane Sphingolipid Transfer Response To Wounding Regulation Of Developmental Process Cell Adhesion	Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Extracellular Matrix Structural Constituent Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Extracellular Region Glomerular Basement Membrane Development Cell Surface Receptor Signaling Pathway Neuromuscular Junction Development Cellular Response To Amino Acid Stimulus Ectodermal Cell Fate Commitment Response To Amino Acid Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Thrombospondin Receptor Activity Neutrophil-mediated Killing Of Gram-negative Bacterium Retinal Blood Vessel Morphogenesis Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway