TBC1D16 and RGS17

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		TBC1D16	RGS17
Name		TBC1 domain family member 16	regulator of G protein signaling 17
Structure		No pdb structure
GO Annotations	Cellular Component	Early Endosome Cytosol	Nucleus Cytoplasm Plasma Membrane Membrane Neuron Projection Synapse
	Molecular Function	GTPase Activator Activity Protein Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Receptor Recycling Regulation Of Cilium Assembly	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction
Pathways		TBC/RABGAPs	G alpha (q) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events
GWAS		Albumin-globulin ratio ( 29403010 ) Hematology traits ( 30576415 ) Mean reticulocyte volume ( 32888494 ) Non-albumin protein levels ( 29403010 ) Serum total protein levels ( 29403010 )	Adult body size ( 32376654 ) Alcohol dependence ( 26365420 ) Apolipoprotein A1 levels ( 32203549 ) Bacterial meningitis ( 31092817 ) Body mass index ( 28892062 ) Cuneus cortex volume ( 31530798 ) Diastolic blood pressure ( 30224653 ) Fasting glucose ( 34059833 ) General risk tolerance (MTAG) ( 30643258 ) HDL cholesterol levels ( 32203549 ) High density lipoprotein cholesterol levels ( 29083408 ) Lipoprotein (a) levels ( 26377243 ) Morning person ( 30696823 ) Pneumococcal meningitis ( 31092817 ) Prostate cancer ( 23535732 ) Triglyceride levels ( 32203549 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		15 interacting genes: GABARAPL1 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP4-12 KRTAP5-9 MAP1LC3A NOTCH2NLA PSMA3 RGS17 RGS20 TNS2 TRAF1	45 interacting genes: ADRB2 AQP1 BOLA2 BOLA2B CHRD CRCT1 CREB5 DHX37 GNAI1 GNAI3 HINT1 HOXA1 HSD3B7 KRTAP4-11 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A NUFIP2 OSTM1 OTX1 PTGER3 RABEP1 RBBP8 RPL10A SLC39A7 SMCP STUB1 TBC1D16 VASN
Entrez ID		125058	26575
HPRD ID		10261	06223
Ensembl ID		ENSG00000167291	ENSG00000091844
Uniprot IDs		Q8TBP0	Q9UGC6
PDB IDs		Not available	1ZV4 6AM3
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Cytosol Autophagosome Maturation Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor Autophagosome Membrane Mitophagy Negative Regulation Of Hepatic Stellate Cell Activation Nitric Oxide Catabolic Process Autophagy Of Mitochondrion Autophagosome Catalase Activity Carbon Monoxide Binding	Keratinization Epidermis Development Tissue Development Protein Binding Intermediate Filament Defense Response To Gram-negative Bacterium [2Fe-2S] Cluster Assembly Identical Protein Binding Negative Regulation Of Smooth Muscle Contraction Iron-sulfur Cluster Assembly Complex