CCR6 and DEFB103B

Number of citations: 0 (PubMedID 11714836)
Data Source: HPRD (in vitro, in vivo)

		CCR6	DEFB103B
Name		C-C motif chemokine receptor 6	defensin beta 103B
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane	Extracellular Region Extracellular Space Golgi Lumen
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity	Protein Binding CCR6 Chemokine Receptor Binding Chemoattractant Activity
	Biological Process	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis	Defense Response Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Killing By Host Of Symbiont Cells Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Symbiont
Pathways		Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events	Beta defensins Defensins
GWAS		Albumin-globulin ratio ( 29403010 ) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229 ) Basal cell carcinoma ( 31174203 ) Crohn's disease ( 28067908 18587394 23850713 21102463 20570966 ) Graves' disease ( 22922229 ) Inflammatory bowel disease ( 23128233 27569725 28067908 ) Keratinocyte cancer (MTAG) ( 31174203 ) Lung cancer ( 28604730 ) Primary biliary cholangitis ( 28425483 ) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901 ) Rheumatoid arthritis ( 30423114 24782177 32723749 24390342 23143596 20453841 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Social autistic-like traits ( 24133439 ) Triglycerides ( 24886709 ) Vitiligo ( 27723757 20526339 )	No GWAS studies recorded
Interacting Genes		5 interacting genes: CCL20 DEFB1 DEFB103B DEFB4A QSOX1	12 interacting genes: AQP6 B3GALT5 CCR6 EBP ERGIC3 ODF4 SCN3B SPATA31A7 SSMEM1 TMEM14B TMEM31 TMPRSS2
Entrez ID		1235	55894
HPRD ID		03498	05968
Ensembl ID		ENSG00000112486	ENSG00000177243
Uniprot IDs		P51684	A0A894JZ42 P81534
PDB IDs		6WWZ	1KJ6
GO Terms Enriched among Interactors		CCR6 Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Humoral Immune Response Defense Response To Gram-negative Bacterium Locomotion Defense Response To Bacterium Chemotaxis Golgi Lumen Defense Response To Other Organism Defense Response To Gram-positive Bacterium Defense Response To Symbiont Killing Of Cells Of Another Organism Response To Bacterium Chemoattractant Activity Cell Killing Cell Chemotaxis Response To Other Organism Positive Chemotaxis Immune Response Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity Response To External Biotic Stimulus Defense Response Phosphatidylinositol-4,5-bisphosphate Binding Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Regulation Of Response To DNA Integrity Checkpoint Signaling Extracellular Space Cell Migration Flavin-dependent Sulfhydryl Oxidase Activity Thymocyte Migration Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Nuclear Speck Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse L-lysine Catabolic Process Negative Regulation Of Translational Elongation Cell Motility Thiol Oxidase Activity Splicing Factor Binding Immune System Process Lysine Catabolic Process Negative Regulation Of Centriole Replication Calcium-mediated Signaling Positive Regulation Of Gene Expression	Membrane PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation C-8 Sterol Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Cholestenol Delta-isomerase Activity Retrograde Transporter Complex, Golgi To ER Thymocyte Migration Entry Receptor-mediated Virion Attachment To Host Cell Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Steroid Delta-isomerase Activity DN2 Thymocyte Differentiation Viral Translation Transporter Complex Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential