CCR6 and DEFB4A

Number of citations: 0 (PubMedID 11714836)
Data Source: HPRD (in vitro, in vivo)

		CCR6	DEFB4A
Name		C-C motif chemokine receptor 6	defensin beta 4A
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane	Extracellular Region Extracellular Space Golgi Lumen
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding CCR6 Chemokine Receptor Binding Chemoattractant Activity
	Biological Process	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis	Chemotaxis Defense Response Immune Response G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Positive Chemotaxis Cell Chemotaxis Antifungal Innate Immune Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Symbiont
Pathways		Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events	Beta defensins Defensins
GWAS		Albumin-globulin ratio ( 29403010 ) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229 ) Basal cell carcinoma ( 31174203 ) Crohn's disease ( 28067908 18587394 23850713 21102463 20570966 ) Graves' disease ( 22922229 ) Inflammatory bowel disease ( 23128233 27569725 28067908 ) Keratinocyte cancer (MTAG) ( 31174203 ) Lung cancer ( 28604730 ) Primary biliary cholangitis ( 28425483 ) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901 ) Rheumatoid arthritis ( 30423114 24782177 32723749 24390342 23143596 20453841 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Social autistic-like traits ( 24133439 ) Triglycerides ( 24886709 ) Vitiligo ( 27723757 20526339 )	No GWAS studies recorded
Interacting Genes		5 interacting genes: CCL20 DEFB1 DEFB103B DEFB4A QSOX1	3 interacting genes: CCR6 KCNA3 TLR4
Entrez ID		1235	1673
HPRD ID		03498	03739
Ensembl ID		ENSG00000112486	ENSG00000171711
Uniprot IDs		P51684	O15263
PDB IDs		6WWZ	1E4Q 1FD3 1FD4 1FQQ 6CS9 8YD6
GO Terms Enriched among Interactors		CCR6 Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Humoral Immune Response Defense Response To Gram-negative Bacterium Locomotion Defense Response To Bacterium Chemotaxis Golgi Lumen Defense Response To Other Organism Defense Response To Gram-positive Bacterium Defense Response To Symbiont Killing Of Cells Of Another Organism Response To Bacterium Chemoattractant Activity Cell Killing Cell Chemotaxis Response To Other Organism Positive Chemotaxis Immune Response Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity Response To External Biotic Stimulus Defense Response Phosphatidylinositol-4,5-bisphosphate Binding Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Regulation Of Response To DNA Integrity Checkpoint Signaling Extracellular Space Cell Migration Flavin-dependent Sulfhydryl Oxidase Activity Thymocyte Migration Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Nuclear Speck Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse L-lysine Catabolic Process Negative Regulation Of Translational Elongation Cell Motility Thiol Oxidase Activity Splicing Factor Binding Immune System Process Lysine Catabolic Process Negative Regulation Of Centriole Replication Calcium-mediated Signaling Positive Regulation Of Gene Expression	B Cell Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Cell Activation Involved In Immune Response B Cell Activation Lymphocyte Activation Involved In Immune Response Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Negative Regulation Of Interleukin-23 Production Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Detection Of Fungus Nitric Oxide Production Involved In Inflammatory Response Wound Healing Involved In Inflammatory Response MHC Class II Biosynthetic Process Thymocyte Migration Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion Signaling Receptor Activity DN2 Thymocyte Differentiation Lipopolysaccharide Receptor Complex Mononuclear Cell Differentiation T Cell Activation Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Detection Of Lipopolysaccharide B Cell Proliferation Involved In Immune Response External Side Of Plasma Membrane Lipopolysaccharide Immune Receptor Activity Leukocyte Differentiation Positive Regulation Of Dendritic Cell Chemotaxis Immune Effector Process Sperm Plasma Membrane Positive Regulation Of Flagellated Sperm Motility Voltage-gated Monoatomic Ion Channel Activity Regulation Of Matrix Metallopeptidase Secretion Regulation Of Interleukin-23 Production Cellular Response To Lipoteichoic Acid Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Intestinal Epithelial Structure Maintenance TRIF-dependent Toll-like Receptor Signaling Pathway NK T Cell Activation Microglia Differentiation T-helper 1 Type Immune Response Regulation Of Dendritic Cell Chemotaxis Lymphocyte Activation Positive Regulation Of Cilium Movement Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Detection Of Molecule Of Bacterial Origin Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Platelet Activation