CLIC1 and RPLP1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CLIC1	RPLP1
Name		chloride intracellular channel 1	ribosomal protein lateral stalk subunit P1
Structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Endoplasmic Reticulum Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Monoatomic Ion Channel Complex Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle	Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Ribonucleoprotein Complex
	Molecular Function	Chloride Channel Activity Protein Binding Oxidoreductase Activity Cadherin Binding	Structural Constituent Of Ribosome Protein Binding Protein Kinase Activator Activity Ribonucleoprotein Complex Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Monoatomic Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Mitochondrial Membrane Potential Platelet Aggregation Chloride Transmembrane Transport	Cytoplasmic Translation Translation Translational Elongation
Pathways		None	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Copper Artenimol	None
GWAS		Adult body size ( 32376654 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Inflammatory bowel disease ( 28067908 ) Mean platelet volume ( 27863252 ) Ulcerative colitis ( 28067908 )	Chronic lymphocytic leukemia ( 23770605 24292274 28165464 ) Male-pattern baldness ( 27182965 ) Non-response to citalopram or escitalopram and depression ( 27622933 )
Interacting Genes		25 interacting genes: AKAP9 ALOX5AP ANXA1 ATP5PB ATP6V0A1 ATP6V0C CEBPA CFTR CPT1A IKBKG LSM1 MEOX2 MYOC NHSL2 NTF4 NUP62 PRDX4 PSMD10 RPLP1 SUMO4 THRA TPRN TRAPPC2 ZNF184 ZNF302	33 interacting genes: ANKRD13B ASCC2 ATP5MF BRD7 C11orf58 C15orf39 CDIPT CDK2AP2 CLIC1 CSNK2A1 EEF1A1 GEMIN7 GSK3B LRIF1 MAP1LC3B MPC2 NSF NUDT21 NUDT3 PDCD4 PFDN1 PPP2CB PTN RPA2 RPLP2 RPS6KA6 SAT1 SGO1 SUOX TAB1 TUBB2A UBE2D3 XRCC6
Entrez ID		1192	6176
HPRD ID		04188	01611
Ensembl ID		ENSG00000213719	ENSG00000137818
Uniprot IDs		O00299 Q53FB0 Q5SRT3	P05386
PDB IDs		1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA 4JZQ 4K0G 4K0N 7F8R 7FBQ	2LBF 4BEH 4V6X