ADD2 and PTPRZ1

Number of citations: 0 (PubMedID 16105548)
Data Source: HPRD (in vivo)

		ADD2	PTPRZ1
Name		adducin 2	protein tyrosine phosphatase receptor type Z1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane F-actin Capping Protein Complex Postsynaptic Density Membrane Cytoplasmic Vesicle Plasma Membrane Raft	Extracellular Region Plasma Membrane Membrane Extracellular Matrix Synapse Perineuronal Net
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Cytoskeletal Anchor Activity Protein Kinase Binding Spectrin Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity Actin Filament Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Hydrolase Activity
	Biological Process	Synapse Assembly Actin Cytoskeleton Organization Hemopoiesis Leukocyte Migration Leukocyte Tethering Or Rolling Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Protein-containing Complex Assembly	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Signal Transduction Axonogenesis Central Nervous System Development Learning Or Memory Neuron Projection Development Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation
Pathways		Miscellaneous transport and binding events	Other interleukin signaling MDK and PTN in ALK signaling
GWAS		Acne (severe) ( 24927181 ) Response to esketamine in treatment resistant depression ( 32724131 )	Hand grip strength ( 27325353 ) Heel bone mineral density ( 30598549 ) Lung adenocarcinoma ( 28604730 )
Interacting Genes		8 interacting genes: ADD1 APP CALM1 FYN PRKACA PRKCD PTPRZ1 RPH3A	13 interacting genes: ADD2 ALK ARHGAP35 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B PTN PTPRF TNR
Entrez ID		119	5803
HPRD ID		00037	01481
Ensembl ID		ENSG00000075340	ENSG00000106278
Uniprot IDs		P35612 Q05DK5	B4DFE7 P23471
PDB IDs		Not available	3JXF 3S97 5AWX 5H08 8FN8 8FN9
GO Terms Enriched among Interactors		Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Growth Factor Receptor Binding Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Calcium-mediated Signaling Regulation Of Dendritic Spine Maintenance Regulation Of Metal Ion Transport Regulation Of Biological Quality Regulation Of Superoxide Anion Generation Regulation Of Monoatomic Ion Transport Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Transport Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Protein Localization To Nucleus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Fc Receptor Mediated Stimulatory Signaling Pathway Modulation Of Chemical Synaptic Transmission Calcium-mediated Signaling Calcium Channel Complex Cellular Response To Peptide Hormone Stimulus Ephrin Receptor Binding Regulation Of Establishment Of Protein Localization Regulation Of Superoxide Metabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Fc-gamma Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Motile Cilium Cell Projection Neuron Projection Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-serine Phosphorylation Positive Regulation Of Protein Transport Membrane Regulation Of Neuron Apoptotic Process Regulation Of Blood Circulation Negative Regulation Of Actin Filament Polymerization Glutamate Receptor Signaling Pathway Learning Or Memory Perinuclear Region Of Cytoplasm Neuron Projection Morphogenesis Cellular Response To Amyloid-beta Sperm Midpiece Cell Projection Morphogenesis	Regulation Of Response To Wounding Cell Migration Regulation Of Oligodendrocyte Differentiation Regulation Of Neuron Projection Development Cell Motility Positive Regulation Of Neuron Projection Development Regulation Of Glial Cell Differentiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Developmental Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Leukocyte Migration Regulation Of Gliogenesis Schaffer Collateral - CA1 Synapse Positive Regulation Of Leukocyte Chemotaxis Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Development Learning Or Memory Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Glial Cell Differentiation Cell Development Nervous System Development Cognition Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Growth Factor Activity Heparin Binding Positive Regulation Of Blood Vessel Branching Learning Positive Regulation Of Cell Projection Organization Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway System Development Regulation Of Blood Vessel Branching Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Gliogenesis Positive Regulation Of Epithelial Cell Proliferation Response To Mechanical Stimulus Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Development