FRA10AC1 and CWC27

Number of citations: 0 (PubMedID 22365833)
Data Source: BioGRID (two hybrid)

		FRA10AC1	CWC27
Name		FRA10A associated CGG repeat 1	CWC27 spliceosome associated cyclophilin
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Phosphatase Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome	MRNA Splicing, Via Spliceosome Protein Folding
Pathways		None	mRNA Splicing - Major Pathway
GWAS		Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321 ) Cerebrospinal fluid AB1-42 levels ( 26252872 29274321 ) Refractive error ( 32231278 )	Adult body size ( 32376654 ) Bladder cancer ( 27206850 ) Central corneal thickness ( 29760442 31798171 ) Diverticular disease ( 30177863 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699 ) Left ventricular global circumferential strain ( 33495596 ) Left ventricular global radial strain ( 33495596 ) Obesity-related traits ( 23251661 ) Refractive error ( 32231278 ) Systolic blood pressure ( 30224653 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 31511532 31630189 )
Novel Interactors		None recorded	7 novel interactors: ERBIN GTF2H2 NLN PPWD1 RNF180 SGTB TRAPPC13
Interacting Genes		27 interacting genes: ADPRS C7orf25 CHERP CWC27 EEF1D GATD3 GDPD2 GLRX3 HABP4 IK KASH5 MAP3K12 MFAP1 MOB2 NKAP PLPPR4 PRPF3 PRPF40A SAP30BP SF3B2 THOC1 TRIM41 TTC14 U2AF1 VPS29 ZCCHC10 ZNF830	5 interacting genes: CLK1 FRA10AC1 HMGA1 MORF4L1 OGT
Entrez ID		118924	10283
HPRD ID		12319	11541
Ensembl ID		ENSG00000148690	ENSG00000153015
Uniprot IDs		Q70Z53	A0A8I5KQK1 A0A8I5KRF5 A0A8I5KUW8 D6REK3 Q6UX04
PDB IDs		Not available	2HQ6 4R3E 5Z56 5Z58 6FF4 6FF7 6YVH 7DVQ 8I0R
GO Terms Enriched among Interactors		RNA Splicing MRNA Processing U2-type Precatalytic Spliceosome MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Nuclear Speck Spliceosomal Complex Nucleic Acid Metabolic Process RNA Metabolic Process Nucleoplasm RNA Binding Cajal Body Nucleobase-containing Compound Metabolic Process Catalytic Step 2 Spliceosome U2-type Spliceosomal Complex Glycerophosphoinositol Inositolphosphodiesterase Activity ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Nucleus Nucleic Acid Binding	None