OLFM3 and MYOC

Number of citations: 0 (PubMedID 12019210)
Data Source: HPRD (in vitro, in vivo)

		OLFM3	MYOC
Name		olfactomedin 3	myocilin
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus AMPA Glutamate Receptor Complex Synapse	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Membrane Cytoplasmic Vesicle Node Of Ranvier Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding
	Biological Process	Signal Transduction Eye Photoreceptor Cell Development	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Signal Transduction Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of JNK Cascade Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Diseases		None	Primary open angle glaucoma
GWAS		Glomerular filtration rate ( 24351856 ) Menarche (age at onset) ( 25231870 ) Metabolite levels ( 23823483 ) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189 ) Urate levels (BMI interaction) ( 25811787 )	Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Glaucoma (primary open-angle) ( 33627673 ) Intake of total sugars ( 31005972 )
Interacting Genes		8 interacting genes: ADAMTSL4 APP DYNLT1 GLRX3 MEOX2 MYOC STUB1 TCF4	41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		118427	4653
HPRD ID		10460	03387
Ensembl ID		ENSG00000118733	ENSG00000034971
Uniprot IDs		B3KTG9 Q6IMJ0 Q96PB7	A0A0S2Z421 Q99972
PDB IDs		Not available	4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF 7SIB 7SIJ 7SJT 7SJU 7SJV 7SJW 7SKD 7SKE 7SKF 7SKG 7T8D 8FRR
GO Terms Enriched among Interactors		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Blood Circulation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Frizzled Binding Identical Protein Binding ERBB2 Signaling Pathway Skeletal Muscle Hypertrophy Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Negative Regulation Of Muscle Hypertrophy Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Cardiac Muscle Hypertrophy Pigment Cell Development ERBB Signaling Pathway Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Positive Regulation Of JNK Cascade Positive Regulation Of Neuron Differentiation Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Positive Regulation Of Protein Import Intracellular Transport Of Viral Protein In Host Cell PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Beta-catenin-TCF7L2 Complex Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Apoptotic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Cellular Response To Norepinephrine Stimulus Regulation Of System Process Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling TFIIB-class Transcription Factor Binding Ubiquitin Conjugating Enzyme Complex	Extracellular Exosome Extracellular Space Extracellular Region Basement Membrane Extracellular Matrix Vesicle Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Protease Binding ADP Metabolic Process Ribonucleoside Diphosphate Catabolic Process Morphogenesis Of A Polarized Epithelium Nucleoside Diphosphate Catabolic Process Nicotinamide Nucleotide Metabolic Process Blood Microparticle Pyruvate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Nucleotide Catabolic Process Pyruvate Kinase Activity Carbohydrate Catabolic Process Extracellular Matrix Structural Constituent Nucleoside Phosphate Catabolic Process Collagen Fibril Organization Animal Organ Development Platelet Alpha Granule Lumen Integrin Binding Cell Adhesion Wound Healing Regulation Of Transepithelial Transport Cell-substrate Adhesion ATP Metabolic Process Heart Development Hexose Metabolic Process Tissue Morphogenesis Actin Cytoskeleton Dense Body Regulation Of Multicellular Organismal Process Organophosphate Catabolic Process Monosaccharide Metabolic Process Regulation Of Cell Migration Carbohydrate Derivative Catabolic Process Generation Of Precursor Metabolites And Energy Integrin-mediated Signaling Pathway Monocarboxylic Acid Metabolic Process Lung Development Tumor Necrosis Factor Binding