CIB3 and TACC3

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid)

		CIB3	TACC3
Name		calcium and integrin binding family member 3	transforming acidic coiled-coil containing protein 3
Structure
GO Annotations	Cellular Component	None	Spindle Pole Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body Mitotic Spindle
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Calcium Ion Homeostasis	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Nuclear Migration Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis
Pathways		None	NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling
GWAS		Lymphocyte count ( 32888494 )	Appendicular lean mass ( 33097823 ) Bladder cancer ( 20972438 24163127 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Hip circumference adjusted for BMI ( 34021172 ) Mean spheric corpuscular volume ( 32888494 ) Subcortical volume (MOSTest) ( 32665545 ) Urinary bladder cancer ( 20348956 )
Interacting Genes		53 interacting genes: ARMC8 BEND7 C17orf50 ENOX2 GMCL1 KASH5 KLF17 LNX1 MEOX1 MEOX2 NANOS3 NME4 PAX5 PAX6 POLR2G POU6F2 RBAK REL SCNM1 SERTAD1 SLPI SP3 SP4 SYPL1 TACC3 TLE5 TRAF5 TRIM14 TRIM2 ZBTB43 ZC2HC1C ZFP1 ZFP57 ZNF146 ZNF177 ZNF180 ZNF19 ZNF276 ZNF317 ZNF329 ZNF398 ZNF426 ZNF552 ZNF559-ZNF177 ZNF578 ZNF597 ZNF620 ZNF664 ZNF688 ZNF774 ZNF835 ZSCAN4 ZSCAN5A	30 interacting genes: AKAP9 ARHGDIG ARNT ARNT2 ASPSCR1 AURKA BEX2 BEX3 CATSPERT CCHCR1 CDC20B CDKL5 CIB3 CLIP4 DRC10 EIF3C GDF15 KAT2A KIZ KLC1 KLHL38 NDEL1 NOD2 NUP54 RNF20 SNX20 SPATA18 TBC1D22B TTF2 VPS37C
Entrez ID		117286	10460
HPRD ID		16713	05601
Ensembl ID		ENSG00000141977	ENSG00000013810
Uniprot IDs		Q96Q77	A0A087WUE2 Q9Y6A5
PDB IDs		6WU5 6WU7 6WUD	5LXN 5LXO 5ODS 5ODT
GO Terms Enriched among Interactors		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding DNA Binding Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Metal Ion Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Binding DNA-binding Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Somite Specification DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding HMG Box Domain Binding Embryonic Camera-type Eye Morphogenesis Segment Specification Somite Development Chromatin	Cytoplasm Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Microtubule-based Process Mitotic Centrosome Separation Centrosome Localization Axon Hillock Centrosome Separation