CISH and PRKCA

Number of citations: 0 (PubMedID 12618484)
Data Source: HPRD (in vitro)

		CISH	PRKCA
Name		cytokine inducible SH2 containing protein	protein kinase C alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex Alphav-beta3 Integrin-PKCalpha Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Cytokine Receptor Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Diacylglycerol Binding Histone H3T6 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Cell Growth Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT	Response To Reactive Oxygen Species Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Desmosome Assembly Chromatin Remodeling Protein Phosphorylation Apoptotic Process Mitotic Nuclear Membrane Disassembly Cell Adhesion Learning Or Memory Response To Mechanical Stimulus Response To Toxic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Translation Central Nervous System Neuron Axonogenesis Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Response To Estradiol Negative Regulation Of Glial Cell Apoptotic Process Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Peptide Hormone Regulation Of MRNA Stability Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Positive Regulation Of Cell Adhesion Positive Regulation Of Exocytosis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Transport Response To Corticosterone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Renal Sodium Ion Absorption Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Response To Interleukin-1 Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Dense Core Granule Biogenesis
Pathways		Interleukin-7 signaling Neddylation Growth hormone receptor signaling	Calmodulin induced events Disinhibition of SNARE formation SHC1 events in ERBB2 signaling Signaling by SCF-KIT Regulation of KIT signaling EGFR Transactivation by Gastrin Inactivation, recovery and regulation of the phototransduction cascade Syndecan interactions Acetylcholine regulates insulin secretion Ca2+ pathway Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerization of the Nuclear Lamina HuR (ELAVL1) binds and stabilizes mRNA WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RET signaling ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
Drugs		None	Phosphatidyl serine Vitamin E Tamoxifen Staurosporine Dequalinium Ingenol mebutate Aprinocarsen Midostaurin Perifosine Ellagic acid Benzoyl peroxide Bryostatin 1 alpha-Tocopherol succinate D-alpha-Tocopherol acetate
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025 ) Cortical surface area (MOSTest) ( 32665545 ) Eosinophil percentage of white cells ( 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Appendicular lean mass ( 33097823 ) Bipolar disorder ( 31043756 ) Body composition traits ( 30026463 ) Brugada syndrome ( 35210625 ) Cardiorespiratory fitness (800m run time) ( 32572135 ) Carotid intima media thickness x smoking interaction ( 32117412 ) Coronary artery calcification ( 23870195 ) Cryptosporidiosis ( 32019797 ) Daytime nap ( 33568662 ) Dilated cardiomyopathy (MTAG) ( 33495596 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Feeling guilty ( 29500382 ) Food addiction ( 27106561 ) Gout ( 22179738 ) Haemorrhoidal disease ( 33888516 ) Height ( 22021425 ) Heschl's gyrus morphology ( 25130324 ) Hypertrophic cardiomyopathy ( 33495596 33495597 ) Hypertrophic cardiomyopathy (MTAG) ( 33495596 ) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597 ) Lateral occipital cortex volume ( 31530798 ) Neuroticism ( 29255261 ) Percent glycated albumin ( 29844224 ) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079 ) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511 ) PR interval ( 32439900 ) QRS complex (12-leadsum) ( 27659466 ) QRS complex (Sokolow-Lyon) ( 27659466 ) QRS duration ( 30012220 27577874 27659466 ) QT interval ( 24952745 29213071 29874175 ) Systolic blood pressure ( 31170924 ) Total glycated albumin levels ( 29844224 )
Interacting Genes		20 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA JAK1 JAK2 JAK3 KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2	230 interacting genes: ACTA1 ADAP1 ADCY5 ADD1 ADD3 ADRA1B AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CACYBP CASR CAVIN2 CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EGLN2 EIF2S1 EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FBXO7 FCGR2B FCGR3A FLNA FLNC FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRK2 GRM1 GRM5 GSK3A GSK3B H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 H3-4 H3C1 HABP4 HAND1 HAND2 HES1 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HR HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MAPKAP1 MAPT MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NF2 NFATC1 NFE2L2 NFKBIA NHERF1 NHERF2 NOS1 NOXA1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PHB2 PICK1 PLA2G4A PLCB1 PLD1 PLD2 POLB PPARA PPARG PPM1A PPP1R14A PRKCZ PRKG1 PSMB4 PTGIR PTPN1 PTPN11 PTPN12 PTPN6 RAC1 RACK1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SMURF1 SNAP23 SNAP25 SPAG1 SPP1 SRC STMN1 STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ
Entrez ID		1154	5578
HPRD ID		03897	01498
Ensembl ID		ENSG00000114737	ENSG00000154229
Uniprot IDs		Q9NSE2	J3KRN5 L7RSM7 P17252 Q7Z727
PDB IDs		Not available	2ELI 3IW4 4DNL 4RA4 8U37 8UAK
GO Terms Enriched among Interactors		Cytokine-mediated Signaling Pathway Cytokine Receptor Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytokine Binding Receptor Complex Growth Hormone Receptor Signaling Pathway Via JAK-STAT External Side Of Plasma Membrane Protein Phosphorylation Regulation Of Cell Population Proliferation Response To Cytokine Response To Peptide Signal Transduction Phosphorylation Growth Hormone Receptor Signaling Pathway Plasma Membrane Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Protein Kinase Activity Erythropoietin-mediated Signaling Pathway Extrinsic Component Of Plasma Membrane Interleukin-15-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-2-mediated Signaling Pathway Kinase Activity Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Diacylglycerol-dependent Serine/threonine Kinase Activity Adaptive Immune Response Interleukin-3 Receptor Activity Histone H3T6 Kinase Activity Regulation Of Receptor Signaling Pathway Via JAK-STAT Intracellular Signal Transduction Leukocyte Activation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-17 Production Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Platelet Aggregation Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway	Regulation Of Biological Quality Regulation Of Transport Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Cell Communication Regulation Of System Process Regulation Of Developmental Process Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Transport Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Developmental Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Cell Development Regulation Of Membrane Potential Cellular Developmental Process Regulation Of Programmed Cell Death Negative Regulation Of Signaling Calmodulin Binding Focal Adhesion Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Blood Circulation Cytosol Negative Regulation Of Signal Transduction Positive Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Development Regulation Of Vesicle-mediated Transport Protein Kinase Binding Regulation Of Protein Metabolic Process Cell Differentiation Glutamatergic Synapse Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Dendritic Spine