TMEM123 and AGR2

Number of citations: 0 (PubMedID 20888340)
Data Source: BioGRID (two hybrid)

		TMEM123	AGR2
Name		transmembrane protein 123	anterior gradient 2, protein disulphide isomerase family member
Structure		No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Membrane Cytoplasmic Vesicle	Extracellular Region Extracellular Space Endoplasmic Reticulum
	Molecular Function	Protein Binding Signaling Receptor Activity	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	None	Inflammatory Response Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response
GWAS		Prostate cancer ( 23535732 ) Vein graft stenosis in coronary artery bypass grafting ( 25881214 )	Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065 ) Iron status biomarkers (ferritin levels) ( 28334935 ) Residual cognition ( 28441426 ) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860 )
Interacting Genes		4 interacting genes: AGR2 MAGEA11 SGTB UBQLN2	87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1
Entrez ID		114908	10551
HPRD ID		06963	05896
Ensembl ID		ENSG00000152558	ENSG00000106541
Uniprot IDs		Q8N131	O95994 Q4JM46
PDB IDs		Not available	2LNS 2LNT
GO Terms Enriched among Interactors		Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of G Protein-coupled Receptor Internalization TRC Complex Lung Goblet Cell Differentiation Response To Endoplasmic Reticulum Stress Positive Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of IRE1-mediated Unfolded Protein Response Dystroglycan Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Mucus Secretion Identical Protein Binding Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Digestive Tract Morphogenesis Epidermal Growth Factor Receptor Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Response To Stress Lung Epithelial Cell Differentiation Lung Cell Differentiation Positive Regulation Of ERBB Signaling Pathway Regulation Of ERAD Pathway Negative Regulation Of Receptor-mediated Endocytosis Protein Targeting To ER Protein Heterooligomerization Establishment Of Protein Localization To Endoplasmic Reticulum	Nuclear Pore Structural Constituent Of Nuclear Pore TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress GET Complex Tail-anchored Membrane Protein Insertion Into ER Membrane RNA Transport Positive Regulation Of ERAD Pathway Protein Binding Nucleus Homologous Chromosome Segregation Regulation Of ERAD Pathway