FBXO32 and MLH1

Number of citations: 0 (PubMedID 20706999)
Data Source: BioGRID (two hybrid)

		FBXO32	MLH1
Name		F-box protein 32	mutL homolog 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Z Disc	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Chiasma Late Recombination Nodule Membrane Nuclear Lumen Mismatch Repair Complex MutLalpha Complex
	Molecular Function	Protein Binding	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP Hydrolysis Activity Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding MutSalpha Complex Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Cellular Response To Dexamethasone Stimulus	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Stress DNA Damage Response Male Meiosis Chromosome Segregation Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Bacterium Female Meiosis Chromosome Segregation Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Meiotic Metaphase I Homologous Chromosome Alignment Meiotic Chromosome Segregation Meiotic Telomere Clustering Homologous Chromosome Segregation Isotype Switching Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Oogenesis Meiotic Spindle Midzone Assembly Meiotic Cell Cycle
Pathways		Neddylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination
Diseases		None	Ovarian cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Colorectal cancer Endometrial Cancer
GWAS		Atrial fibrillation ( 29892015 30061737 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Glaucoma ( 30054594 ) Glaucoma (primary open-angle) ( 29891935 33627673 ) Intraocular pressure ( 29617998 29785010 30054594 31959993 ) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603 ) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603 ) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603 ) Psychosis proneness (hypomanic personality scale) ( 28525603 )	Alanine aminotransferase levels ( 33547301 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Platelet distribution width ( 32888494 ) Proximal colorectal cancer ( 33632709 ) Schizophrenia ( 28991256 ) Subjective response to lithium treatment ( 26503763 )
Interacting Genes		13 interacting genes: CDC34 CDK2 EIF3F KDM2A MLH1 MYC MYOD1 MYOG SH3GL1 SH3GL2 SH3GL3 SKP1 TTN	139 interacting genes: - ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ALDOB ANXA6 AP1B1 AP2B1 APRT ARAF ASS1 ATF2 BAAT BLM BRCA1 BTBD2 C9orf152 CAB39L CAPN5 CASP3 CBY2 CCDC180 CCDC33 CCDC74B CDCA7L CDKL5 CEP126 CEP76 CKAP4 CKB CTSV CYLC2 DDX47 EEF1G EEF2 EIF2A ELP6 ENKD1 EXO1 EXOC3 FAM228A FAM50B FAM90A1 FBXO32 FCGBP FLNB FRAT2 FRMD6 GABARAP GSTP1 HDAC6 IGKC ISY1 KPNA2 KPNA5 KPRP LEF1 LGALS4 LUC7L3 LY96 MAGEA8 MAP2K6 MBD3L1 MBD4 MLH3 MORN3 MPG MSH2 MSH3 MSH4 MSH5 MUC2 MYC MYL6 MYOG NANOS3 NDRG1 NELFA NME4 NT5C3B ORC4 PARP12 PARVA PCNA PER2 PIP4K2B PMS1 PMS2 PPP1R13B PPP2CB PRR5L PSMA1 PTGDS PTPN3 PTPRH RAD23B RAD9A RADX RAPGEFL1 RBM48 RSPH3 SEC61A1 SELENBP1 SERPINF1 SMAD1 SPATA8 SQSTM1 STAP2 STX17 SYF2 TASOR2 TDRD7 TFAP2D TLE5 TRIM23 TRIM29 TRMO TSGA13 TXN TXN2 U2AF1 UBOX5 VAMP8 XPA ZBED1 ZC3H11A ZER1 ZFP57 ZFP90 ZMAT5 ZNF177 ZNF212 ZNF474 ZNF559-ZNF177 ZNF774
Entrez ID		114907	4292
HPRD ID		05966	00390
Ensembl ID		ENSG00000156804	ENSG00000076242
Uniprot IDs		I6L984 Q0VAQ6 Q498Y9 Q969P5	A0A087WX20 A0A669KAW3 A0AAQ5BGN3 A0AAQ5BGZ2 H0Y818 P40692 Q59EG3
PDB IDs		Not available	3RBN 4P7A 5U5P 6WBA 6WBB 6WBC 7M60
GO Terms Enriched among Interactors		Myotube Differentiation Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle E-box Binding Striated Muscle Cell Differentiation Skeletal Muscle Cell Differentiation Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Skeletal Muscle Fiber Development Striated Muscle Cell Development Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Fate Commitment Muscle Cell Development Muscle Cell Differentiation Chromosome Organization Positive Regulation Of Striated Muscle Tissue Development Regulation Of Myoblast Fusion Positive Regulation Of Skeletal Muscle Tissue Development DNA-binding Transcription Activator Activity Regulation Of Skeletal Muscle Tissue Development Mitotic Cell Cycle Phase Transition Central Nervous System Development Skeletal Muscle Fiber Development Cell Cycle Phase Transition Cellular Response To Cytokine Stimulus Myotube Cell Development Protein Dimerization Activity Condensed Chromosome Cellular Response To Estradiol Stimulus Regulation Of Striated Muscle Tissue Development Detection Of Mechanical Stimulus Regulation Of Myotube Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Response To Peptide Response To Cytokine Transcription Regulator Complex Male Germ Cell Nucleus Condensed Nuclear Chromosome Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Presynapse Double-strand Break Repair Via Nonhomologous End Joining Euchromatin Identical Protein Binding Positive Regulation Of DNA Metabolic Process	Mismatch Repair Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity Cellular Response To Stress Apoptotic Signaling Pathway Response To Estradiol DNA Damage Response Dinucleotide Insertion Or Deletion Binding Intrinsic Apoptotic Signaling Pathway Response To Corticosteroid DNA Repair Mismatch Repair Complex DNA Metabolic Process Protein Binding Response To Glucocorticoid Damaged DNA Binding Response To Hydrogen Peroxide Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Response To Dexamethasone Mitotic DNA Integrity Checkpoint Signaling Somatic Cell DNA Recombination Signal Transduction In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Response To Reactive Oxygen Species MutSbeta Complex Dinucleotide Repeat Insertion Binding Response To Steroid Hormone Nucleus Response To Stress Somatic Hypermutation Of Immunoglobulin Genes DNA Recombination DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Fructose-bisphosphate Aldolase Activity Somatic Diversification Of Immune Receptors Via Somatic Mutation Single Guanine Insertion Binding MutLalpha Complex Response To Oxidative Stress Cellular Response To Corticosteroid Stimulus Mucus Secretion Response To Radiation Single-stranded DNA Binding P53 Binding Response To UV Mitotic Intra-S DNA Damage Checkpoint Signaling Signal Sequence Binding Guanine/thymine Mispair Binding Satellite DNA Binding Somatic Diversification Of Immunoglobulins