| Name |
cholinergic receptor nicotinic beta 4 subunit |
cholinergic receptor nicotinic alpha 5 subunit |
| Structure |
|
No pdb structure
|
| GO Annotations |
Cellular Component |
|
|
| Molecular Function |
|
|
| Biological Process |
|
|
| Pathways |
|
|
| Drugs |
|
|
| GWAS |
- Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028
)
- Attention function in attention deficit hyperactive disorder ( 26174813
)
- Autism spectrum disorder or schizophrenia ( 28540026
)
- Benign childhood epilepsy with centro-temporal spikes ( 32580138
)
- BMI (smoking interaction) ( 28443625
)
- BMI in smokers ( 28443625
)
- Body mass index (joint analysis main effects and smoking interaction) ( 28443625
)
- Chronic obstructive pulmonary disease ( 30804561
)
- Chronic obstructive pulmonary disease x ever smoker interaction (1df) ( 33106845
)
- Coronary artery disease ( 33020668
32469254
)
- Diffusing capacity of carbon monoxide ( 30694715
)
- Exhaled carbon monoxide levels ( 25072098
)
- Gut microbiota relative abundance (Parabacteroides) ( 33208821
)
- Lung adenocarcinoma ( 28604730
)
- Lung cancer ( 18385738
28604730
18780872
31577861
)
- Lung cancer in ever smokers ( 28604730
)
- Nicotine dependence ( 18385739
26440539
)
- Post bronchodilator FEV1 ( 26634245
)
- Post bronchodilator FEV1/FVC ratio ( 26634245
)
- Post bronchodilator FEV1/FVC ratio in COPD ( 26634245
)
- Refractive error ( 32231278
)
- Schizophrenia ( 29483656
25056061
)
- Small cell lung carcinoma ( 28604730
)
- Smoking status (heavy vs light) ( 28520984
)
- Squamous cell lung carcinoma ( 28604730
)
- Sudden cardiac arrest ( 21658281
)
|
|
| Interacting Genes |
6 interacting genes:
CHRNA2
CHRNA3
CHRNA4
CHRNA5
MEOX2
UBQLN1
|
1 interacting genes:
CHRNB4
|
| Entrez ID |
1143 |
1138 |
| HPRD ID |
00337
|
00334
|
| Ensembl ID |
ENSG00000117971
|
ENSG00000169684
|
| Uniprot IDs |
P30926
|
H0YM98
P30532
Q6EWN4
|
| PDB IDs |
6PV7
6PV8
|
Not available
|
| GO Terms Enriched among Interactors |
|
|