GABARAPL2 and TP53INP2

Number of citations: 25 (PubMedID 20010805)
Data Source: BioGRID (two hybrid)

		GABARAPL2	TP53INP2
Name		GABA type A receptor associated protein like 2	tumor protein p53 inducible nuclear protein 2
Structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle	Nucleus Cytoplasm Autophagosome Cytosol PML Body Cytoplasmic Vesicle
	Molecular Function	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding	Protein Binding Ubiquitin Binding
	Biological Process	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process	Autophagosome Assembly Osteoblast Differentiation Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Autophagy Intracellular Protein Localization Macroautophagy Positive Regulation Of DNA-templated Transcription Negative Regulation Of Protein Localization
Pathways		Macroautophagy TBC/RABGAPs	None
GWAS		Age at first sexual intercourse ( 34211149 ) Blood protein levels ( 30072576 ) Pancreatic cancer ( 25086665 )	Bipolar disorder ( 31043756 ) Colorectal cancer or advanced adenoma ( 30510241 ) Estimated glomerular filtration rate ( 30604766 ) Fish- and plant-related diet ( 32066663 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Urate levels ( 31578528 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		103 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774	3 interacting genes: BECN2 GABARAPL2 MAP1LC3A
Entrez ID		11345	58476
HPRD ID		16246	15546
Ensembl ID		ENSG00000034713	ENSG00000078804
Uniprot IDs		P60520	Q8IXH6
PDB IDs		4CO7 6H8C 7LK3 7YO8 8Q6Q	7YO9 8T31 8T32 8T33 8T35 8T36 8T4T
GO Terms Enriched among Interactors		Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding	Cellular Response To Nitrogen Starvation Mitophagy Autophagy Of Mitochondrion Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Cellular Response To Starvation Phosphatidylethanolamine Binding Response To Starvation Cellular Response To Nutrient Levels Autophagy Response To Nutrient Levels Autophagosome Maturation Autophagosome Membrane Autophagosome Organelle Assembly Phospholipid Binding Protein-containing Complex Disassembly G Protein-coupled Receptor Catabolic Process Microtubule Binding Cellular Response To Oxygen-glucose Deprivation Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I Cellular Response To Stress Ubiquitin Protein Ligase Binding Response To Iron(II) Ion Catabolic Process Response To Oxygen-glucose Deprivation Autolysosome Organelle Organization Protein Localization To Endoplasmic Reticulum GABA Receptor Binding Cellular Component Assembly Positive Regulation Of ATP-dependent Activity Response To Lead Ion Receptor Catabolic Process Phosphatidylinositol 3-kinase Binding Cellular Response To Copper Ion SMAD Protein Signal Transduction P38MAPK Cascade Phagophore Assembly Site Intra-Golgi Vesicle-mediated Transport Regulation Of ATP-dependent Activity Response To Iron Ion Response To Copper Ion Response To Stress Late Endosome To Vacuole Transport Cytoplasmic Vesicle Beta-tubulin Binding