CTRC and PHKG1

Number of citations: 0 (PubMedID 2365696)
Data Source: HPRD (in vitro)

		CTRC	PHKG1
Name		chymotrypsin C	phosphorylase kinase catalytic subunit gamma 1
Structure
GO Annotations	Cellular Component	None	Cytoplasm Cytosol Phosphorylase Kinase Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Phosphorylase Kinase Activity Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Serine Kinase Activity
	Biological Process	Proteolysis Intracellular Calcium Ion Homeostasis	Carbohydrate Metabolic Process Glycogen Metabolic Process Signal Transduction
Pathways		Developmental Lineage of Pancreatic Acinar Cells	Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis)
Drugs		None	Fostamatinib
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis Tropical calcific pancreatitis	None
GWAS		Alcoholic chronic pancreatitis ( 28754779 )	Macular telangiectasia type 2 ( 33654266 ) Multiple sclerosis ( 31604244 ) Plasma free amino acid levels ( 30659259 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 )
Interacting Genes		20 interacting genes: CYSRT1 GIPC2 KRT34 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP3-1 KRTAP6-2 KRTAP9-2 MDFI NEDD8 NFKBID PHKG1 SERPINA3 SPINK1 SPMIP9 ST13 UBC VGLL3	4 interacting genes: CALM1 CTRC MAPT PHKG2
Entrez ID		11330	5260
HPRD ID		03242	01404
Ensembl ID		ENSG00000162438	ENSG00000164776
Uniprot IDs		Q99895	B7Z6U2 Q16816
PDB IDs		4H4F	8JFK 8JFL 8XY7 8XYA 8XYB
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Protein Tag Activity	Regulation Of Calcium-mediated Signaling Enzyme Binding Multivesicular Body, Internal Vesicle Lumen Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Synaptic Plasticity Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Protein Kinase C Signaling Positive Regulation Of Cell Growth Membrane Raft Double-stranded DNA Binding Positive Regulation Of Growth Epidermal Growth Factor Binding ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Main Axon Regulation Of Tubulin Deacetylation Negative Regulation Of Mitochondrial Fission Negative Regulation Of Tubulin Deacetylation Lipoprotein Particle Binding Neurofibrillary Tangle Assembly Intracellular Distribution Of Mitochondria Neurofibrillary Tangle Positive Regulation Of Protein Localization To Synapse Plus-end-directed Organelle Transport Along Microtubule Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Phosphorylase Kinase Complex Phosphorylase Kinase Activity Positive Regulation Of Glycogen Catabolic Process Regulation Of Glycogen Catabolic Process Cellular Response To Growth Factor Stimulus Learning Or Memory Cellular Response To Brain-derived Neurotrophic Factor Stimulus Inclusion Body Assembly Minor Groove Of Adenine-thymine-rich DNA Binding Salivary Gland Morphogenesis