IRAK3 and CDCA5

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		IRAK3	CDCA5
Name		interleukin 1 receptor associated kinase 3	cell division cycle associated 5
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Chromatin Binding Protein Binding Protein-containing Complex Binding
	Biological Process	Positive Regulation Of Cytokine Production Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction Toll Signaling Pathway Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAPK Cascade Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Double-strand Break Repair Mitotic Sister Chromatid Cohesion Cell Division
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling	Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Resolution of Sister Chromatid Cohesion
Drugs		Fostamatinib	None
GWAS		Response to esketamine in treatment resistant depression ( 32724131 ) Smooth-surface caries ( 24556642 ) White blood cell count (basophil) ( 29403010 )	No GWAS studies recorded
Interacting Genes		17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	9 interacting genes: CDK1 IRAK3 KDM1A NAA11 RPAIN SENP2 TTLL3 WAPL XRCC6
Entrez ID		11213	113130
HPRD ID		05123	13016
Ensembl ID		ENSG00000090376	ENSG00000146670
Uniprot IDs		Q9Y616	Q96FF9
PDB IDs		5UKE 6RUU 6ZIW	Not available
GO Terms Enriched among Interactors		Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Endosome Membrane Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Type I Interferon Production Toll Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Activation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Oxygen-containing Compound Immune Response-activating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Signaling Adaptor Activity Response To Interleukin-1 Regulation Of Immune Response Positive Regulation Of Immune Response Immune Response-regulating Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Cellular Response To Lipid Non-canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process Regulation Of Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Defense Response To Symbiont	Protein Modification Process Regulation Of DNA Metabolic Process Regulation Of DNA Replication Chromosome, Telomeric Region Telomeric DNA Binding Cellular Response To Gamma Radiation Cyclin Binding Nucleoplasm Negative Regulation Of Metabolic Process Pronuclear Fusion Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Chromosome Organization Negative Regulation Of Macromolecule Metabolic Process Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Gamma Radiation Positive Regulation Of Protein Modification Process Cellular Response To Ionizing Radiation Positive Regulation Of Macrophage Tolerance Induction Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity ATP-dependent Protein-DNA Unloader Activity Negative Regulation Of Chromatin Binding Protein-glycine Ligase Activity, Initiating Protein Polyglycylation Protein-glycine Ligase Activity Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Protein Localization To Chromosome Protein Metabolic Process Mitotic DNA Replication Muscle Cell Development DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Response To Toxic Substance DNA End Binding Response To Radiation Ku70:Ku80 Complex Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Protein Ubiquitination PML Body Protein N-terminal-serine Acetyltransferase Activity Protein Modification By Small Protein Removal Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Post-translational Protein Modification Protein Demethylase Activity Regulation Of DNA Endoreduplication Nucleus