PKP3 and DSC3

Number of citations: 49 (PubMedID 12707304)
Data Source: HPRD (in vivo, two hybrid)

		PKP3	DSC3
Name		plakophilin 3	desmocollin 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Membrane Cell Junction Desmosome Anchoring Junction	Cornified Envelope Extracellular Region Cytoplasm Plasma Membrane Cell-cell Junction Membrane Cell Junction Desmosome Anchoring Junction
	Molecular Function	RNA Binding Protein Binding Enzyme Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cadherin Binding Involved In Cell-cell Adhesion	Calcium Ion Binding Gamma-catenin Binding Metal Ion Binding
	Biological Process	Desmosome Assembly Regulation Of Cytokine Production Involved In Immune Response Desmosome Organization Regulation Of Translation Cell Adhesion Regulation Of Gene Expression Epithelial Structure Maintenance Positive Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Regulation Of Hair Follicle Development Protein Localization To Plasma Membrane Epithelial Cell-cell Adhesion Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization	In Utero Embryonic Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Protein Stabilization Cell-cell Adhesion
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Diseases		None	Hypotrichosis and recurrent skin vesicles
GWAS		Anorectal malformation ( 31136621 ) Lymphocyte count ( 32888494 )	Bronchopulmonary dysplasia ( 23897914 ) Hand grip strength (Mahalanobis distance) ( 32235003 ) Metabolite levels ( 31628463 ) Obesity-related traits ( 23251661 ) Protein quantitative trait loci ( 18464913 ) Supraventricular ectopy ( 29618737 ) Type 2 diabetes ( 31049640 )
Interacting Genes		10 interacting genes: DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP IQUB JUP KRT18	5 interacting genes: CTNNB1 JUP PKP3 PKP4 UCHL5
Entrez ID		11187	1825
HPRD ID		05711	02604
Ensembl ID		ENSG00000184363	ENSG00000134762
Uniprot IDs		Q9Y446	Q14574
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Desmosome Cornified Envelope Desmosome Organization Cell-cell Adhesion Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Anchoring Junction Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell-cell Junction Organization Cell-cell Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Regulation Of Action Potential Homotypic Cell-cell Adhesion Cell Junction Cell Junction Organization Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Calcium Ion Binding Positive Regulation Of Protein Localization To Cell-cell Junction Regulation Of Muscle Contraction Adherens Junction Regulation Of Heart Contraction Ficolin-1-rich Granule Membrane Regulation Of Protein Localization To Cell-cell Junction Desmosome Assembly Regulation Of Muscle System Process Regulation Of Blood Circulation Gamma-catenin Binding Extracellular Exosome Cell-cell Junction Assembly Epithelial Cell-cell Adhesion Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Intermediate Filament Structural Molecule Activity Regulation Of Biological Quality Maternal Process Involved In Female Pregnancy Response To Progesterone Regulation Of System Process Regulation Of P38MAPK Cascade	Desmosome Adherens Junction Cornified Envelope Alpha-catenin Binding Cell-cell Junction Assembly Anchoring Junction Cell-cell Junction Organization Cell-cell Adhesion Catenin-TCF7L2 Complex Intercalated Disc Cell-cell Junction Cell Junction Cellular Response To Indole-3-methanol Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cell Junction Assembly Response To Indole-3-methanol Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Cadherin Binding Cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Cell Junction Organization Epithelial Cell-cell Adhesion Catenin Complex Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Midbrain Development Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Detection Of Mechanical Stimulus Protein-DNA Complex Nuclear Receptor Binding Regulation Of Cell Adhesion Cardiac Conduction Skin Development Regulation Of Action Potential Homotypic Cell-cell Adhesion Positive Regulation Of Telomere Maintenance Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Gamma-catenin-TCF7L2 Complex Regulation Of Cell Cycle Regulation Of Cardiac Muscle Contraction Regulation Of Embryonic Development Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex