PSIP1 and HMGA2

Number of citations: 95 (PubMedID 36835656)
Data Source: BioGRID (proximity labelling technology, far western blotting)

		PSIP1	HMGA2
Name		PC4 and SRSF1 interacting protein 1	high mobility group AT-hook 2
Structure			No pdb structure
GO Annotations	Cellular Component	Euchromatin Heterochromatin Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Periphery	Nuclear Chromosome Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding DNA Binding, Bending Enzyme Binding Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding
	Biological Process	MRNA 5'-splice Site Recognition Chromatin Remodeling Response To Oxidative Stress Response To Heat Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Regulation Of DNA-templated Transcription Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Response To Virus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Cell Proliferation In Forebrain Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Chromosome Condensation Adrenal Gland Development Heterochromatin Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Multicellular Organism Growth Intracellular Signal Transduction Endodermal Cell Differentiation Chondrocyte Proliferation Positive Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Host-mediated Suppression Of Viral Transcription Fat Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Mesodermal Cell Differentiation Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Regulation Of Growth Hormone Secretion Lung Epithelium Development Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Adipose Tissue Development Fat Pad Development Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Protein Serine/threonine Kinase Activity Stem Cell Proliferation Regulation Of Peptide Hormone Secretion Oncogene-induced Cell Senescence Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of WDR5-containing histone-modifying complexes	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
GWAS		No GWAS studies recorded	Adverse response to drug ( 30420678 ) Aortic root size ( 19584346 ) Appendicular lean mass ( 33097823 ) Axial length ( 24144296 ) Birth length ( 25281659 ) Birth weight ( 31043758 27680694 23202124 ) Body size at age 10 ( 32376654 ) Brain structure ( 22504417 ) Childhood body mass index ( 33045005 ) Chin dimples ( 27182965 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Cortical surface area (global PC1) ( 32198502 ) Cortical volume ( 32963231 ) Fasting insulin ( 34059833 ) Haemorrhoidal disease ( 33888516 ) Head circumference (infant) ( 22504419 ) Heart rate response to exercise ( 29769521 ) Heel bone mineral density ( 30598549 ) Height ( 25282103 18391952 28552196 20881960 18391951 18391950 25429064 19343178 21998595 20397748 23563607 22021425 31562340 17767157 ) Hip circumference ( 25673412 ) Hip circumference adjusted for BMI ( 25673412 34021172 ) Hip index ( 34021172 ) Infant length ( 25281659 ) Late-onset Alzheimer's disease ( 27770636 ) Medication use (drugs used in diabetes) ( 31015401 ) Neutrophil count ( 32888494 ) Offspring birth weight ( 31043758 ) Permanent tooth development ( 21931568 ) Plateletcrit ( 32888494 ) Polycystic ovary syndrome ( 22885925 ) Primary tooth development (number of teeth) ( 20195514 23704328 ) Primary tooth development (time to first tooth eruption) ( 23704328 20195514 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 31928498 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 32499647 28869590 20581827 30297969 30054458 29358691 26961502 25102180 24509480 22885922 ) Type 2 diabetes nephropathy ( 21150874 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 ) Youthful appearance (self-reported) ( 32339537 )
Interacting Genes		18 interacting genes: CASP3 CASP7 CDC42 CEBPA CSNK2A1 HCFC1 HMGA1 HMGA2 KMT2A MAPK6 MTDH OGT SP1 SRSF1 SUB1 SUMO1 UBC USP7	21 interacting genes: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 KAT2B MDM2 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP TP53
Entrez ID		11168	8091
HPRD ID		04688	02827
Ensembl ID		ENSG00000164985	ENSG00000149948
Uniprot IDs		O75475	F5H2A4 F5H6H0 P52926 Q1M183
PDB IDs		1Z9E 2B4J 2M16 2MSR 2MTN 2N3A 3F9K 3HPG 3HPH 3U88 3ZEH 4FU6 5N88 5OYM 5YI9 6EMO 6EMP 6EMQ 6EMR 6S01 6TRJ 6TVM 6ZV0 7OUF 7OUG 7OUH 7PEL 7Z1Z 8CBN 8CBQ 8PC5 8PC6 8PEO 8PEP	Not available
GO Terms Enriched among Interactors		Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Metabolic Process Rhythmic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Execution Phase Of Apoptosis Negative Regulation Of Biosynthetic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of RNA Metabolic Process Cellular Response To Staurosporine Senescence-associated Heterochromatin Focus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Pyroptotic Inflammatory Response Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis 5'-deoxyribose-5-phosphate Lyase Activity Oncogene-induced Cell Senescence Negative Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Regulation Of Protein Stability Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process	Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Organization Nucleus Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Remodeling Regulation Of Cell Differentiation Ubiquitin Protein Ligase Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Peptide Hormone DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Process DNA Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Response To Stress Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Response To Oxidative Stress