LDB3 and MYOZ3

Number of citations: 0 (PubMedID 11842093)
Data Source: HPRD (two hybrid, in vitro)

		LDB3	MYOZ3
Name		LIM domain binding 3	myozenin 3
Structure			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton Adherens Junction Z Disc Pseudopodium Filamentous Actin Cell Projection Perinuclear Region Of Cytoplasm	Cytoplasm Actin Cytoskeleton Z Disc
	Molecular Function	Actin Binding Protein Kinase C Binding Protein Binding Cytoskeletal Protein Binding Enzyme Binding Metal Ion Binding Muscle Alpha-actinin Binding	Actin Binding Protein Binding Telethonin Binding FATZ Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Sarcomere Organization Muscle Structure Development	None
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)	None
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Heel bone mineral density ( 30598549 ) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 )	Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 )
Interacting Genes		7 interacting genes: ACTN2 ANKRD2 MYOZ1 MYOZ2 MYOZ3 TFCP2 TP53	71 interacting genes: ABI2 ACTN1 ACTN2 AKIRIN2 ASPG ATOSB ATXN1L BAG4 BCAS2 C10orf55 CCDC57 CIMIP2B CREM CRLF3 DAZAP2 DMRT3 EFS ENKD1 EXOC8 FAM168B FHL3 FHL5 FLNC GCM2 GOLGA6A GOLGA6L9 HSF2BP KANK2 KRT34 KRT36 KRT75 KRTAP19-5 KRTAP19-6 KRTAP6-1 KRTAP7-1 KRTAP8-1 KYNU LDB3 LENG8 LMO2 LMO3 LMO4 LONRF1 MAPK6 MORN3 MRPL38 MYO15B NEK6 NUTF2 PDLIM3 PITX1 PM20D2 PPP3CA PPP3CB PRDM6 PSMB4 PTK6 RINT1 RNF125 RUSC1 SPMIP5 TBX15 TCAP TEKT4 TRAPPC6A TSC1 TSSK3 UFSP1 YPEL3 ZNF620 ZNF688
Entrez ID		11155	91977
HPRD ID		16172	17624
Ensembl ID		ENSG00000122367	ENSG00000164591
Uniprot IDs		A0A0S2Z501 A0A0S2Z530 A0A8I5KV04 O75112 V5T7C5	Q8TDC0
PDB IDs		1RGW 4YDP	Not available
GO Terms Enriched among Interactors		FATZ Binding Telethonin Binding Z Disc Sarcomere Organization Skeletal Muscle Fiber Adaptation Actin Cytoskeleton Actin Binding Actomyosin Structure Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Pseudopodium Negative Regulation Of Calcium-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Structural Constituent Of Muscle Molecular Condensate Scaffold Activity Regulation Of DNA-templated Transcription Sarcomere Regulation Of RNA Biosynthetic Process MRNA Transcription Actin Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Regulation Of RNA Metabolic Process Actin Filament Uncapping Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Skeletal Muscle Tissue Regeneration Actin Filament-based Process Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Calcium-mediated Signaling Titin Z Domain Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate PML Body Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Striated Muscle Tissue Development Negative Regulation Of RNA Metabolic Process Microspike Assembly Positive Regulation Of Thymocyte Apoptotic Process	Z Disc Intermediate Filament Muscle Cell Development Cytoskeletal Protein Binding Cytoskeleton Organization Protein Binding Titin Z Domain Binding Sarcomere Organization Pseudopodium FATZ Binding Calmodulin-dependent Protein Phosphatase Activity Striated Muscle Cell Development Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Organelle Organization Actin Filament Stress Fiber Cell Projection Protein Serine/threonine Phosphatase Complex