LDB3 and MYOZ2

Number of citations: 0 (PubMedID 11842093)
Data Source: HPRD (in vivo, two hybrid)

		LDB3	MYOZ2
Name		LIM domain binding 3	myozenin 2
Structure			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton Adherens Junction Z Disc Pseudopodium Filamentous Actin Cell Projection Perinuclear Region Of Cytoplasm	Cytoplasm Actin Cytoskeleton Sarcomere Z Disc
	Molecular Function	Actin Binding Protein Kinase C Binding Protein Binding Cytoskeletal Protein Binding Enzyme Binding Metal Ion Binding Muscle Alpha-actinin Binding	Actin Binding Protein Binding Protein Phosphatase 2B Binding Telethonin Binding FATZ Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Sarcomere Organization Muscle Structure Development	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)	None
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Heel bone mineral density ( 30598549 ) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 )	HDL cholesterol levels ( 32203549 ) Immature fraction of reticulocytes ( 32888494 ) PR interval ( 32439900 ) Refractive error ( 32231278 )
Interacting Genes		7 interacting genes: ACTN2 ANKRD2 MYOZ1 MYOZ2 MYOZ3 TFCP2 TP53	18 interacting genes: ACTN1 ACTN2 ACTN4 CRK DRICH1 EWSR1 FLNC HSPB2 LDB3 MBLAC1 MKRN3 MYB PDLIM3 PPP3CA PPP3CB RBPMS WWOX ZDHHC17
Entrez ID		11155	51778
HPRD ID		16172	05724
Ensembl ID		ENSG00000122367	ENSG00000172399
Uniprot IDs		A0A0S2Z501 A0A0S2Z530 A0A8I5KV04 O75112 V5T7C5	Q9NPC6
PDB IDs		1RGW 4YDP	Not available
GO Terms Enriched among Interactors		FATZ Binding Telethonin Binding Z Disc Sarcomere Organization Skeletal Muscle Fiber Adaptation Actin Cytoskeleton Actin Binding Actomyosin Structure Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Pseudopodium Negative Regulation Of Calcium-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Structural Constituent Of Muscle Molecular Condensate Scaffold Activity Regulation Of DNA-templated Transcription Sarcomere Regulation Of RNA Biosynthetic Process MRNA Transcription Actin Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Regulation Of RNA Metabolic Process Actin Filament Uncapping Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Skeletal Muscle Tissue Regeneration Actin Filament-based Process Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Calcium-mediated Signaling Titin Z Domain Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate PML Body Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Striated Muscle Tissue Development Negative Regulation Of RNA Metabolic Process Microspike Assembly Positive Regulation Of Thymocyte Apoptotic Process	Z Disc Cytoskeletal Protein Binding Muscle Cell Development Pseudopodium Actin Cytoskeleton Organization Actin Filament-based Process Actin Binding Cell Development Stress Fiber Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Transcription Coactivator Activity Actin Cytoskeleton Sarcomere Organization Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Cortical Actin Cytoskeleton Identical Protein Binding Positive Regulation Of Monoatomic Ion Transport Protein Serine/threonine Phosphatase Complex Platelet Alpha Granule Lumen Postsynaptic Actin Cytoskeleton Positive Regulation Of Calcium Ion Import Across Plasma Membrane Cytoskeleton Organization Enzyme Binding Actin Filament Binding Striated Muscle Cell Development Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Muscle Alpha-actinin Binding Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Calcineurin-NFAT Signaling Cascade Actomyosin Structure Organization Regulation Of Monoatomic Ion Transmembrane Transport Glutamatergic Synapse Positive Regulation Of Calcium Ion Import Positive Regulation Of RNA Metabolic Process Focal Adhesion Assembly Calcineurin-mediated Signaling Calcium Ion Binding Skeletal Muscle Fiber Development Filamentous Actin Transmembrane Transporter Binding Muscle Structure Development Regulation Of Metal Ion Transport