AP4S1 and TEAD3

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		AP4S1	TEAD3
Name		adaptor related protein complex 4 subunit sigma 1	TEA domain transcription factor 3
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Endomembrane System Membrane AP-4 Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	None	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Protein Targeting Intracellular Protein Localization Protein Transport Vesicle-mediated Transport	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Female Pregnancy Hippo Signaling Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Asymmetric Neuroblast Division
Pathways		Lysosome Vesicle Biogenesis	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Regulation of PD-L1(CD274) transcription
Diseases		Cerebral palsy	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Mean corpuscular volume ( 32888494 )	Appendicular lean mass ( 33097823 ) Birth weight ( 31043758 ) Colorectal cancer or advanced adenoma ( 30510241 ) Offspring birth weight ( 31043758 )
Interacting Genes		6 interacting genes: AFP APP GRB2 GTF2I HTR6 TEAD3	14 interacting genes: AP4S1 CTBP2 E2F1 E2F3 KIFC2 MYH7 PHB2 PIDD1 SUMO2 VGLL1 VGLL2 VGLL3 WWTR1 YAP1
Entrez ID		11154	7005
HPRD ID		06257	04411
Ensembl ID		ENSG00000100478	ENSG00000007866
Uniprot IDs		Q9Y587	A0A7P0SNI2 Q99594
PDB IDs		Not available	5EMW 7CNL 7ZJQ 8P0M
GO Terms Enriched among Interactors		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Glial Cell Development Guanyl-nucleotide Exchange Factor Adaptor Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Grb2-EGFR Complex Asymmetric Neuroblast Division Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Supramolecular Fiber Organization Cellular Response To Norepinephrine Stimulus Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Neurotrophin TRKA Receptor Binding Histamine Receptor Activity Axon Choice Point Recognition Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heparan Sulfate Binding Signaling Receptor Activator Activity Ovulation From Ovarian Follicle Peptidase Activator Activity	Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Fat Cell Differentiation DNA-binding Transcription Activator Activity Positive Regulation Of Macromolecule Metabolic Process Hippo Signaling Heart Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Transcription Corepressor Activity Regulation Of Gene Expression Enterocyte Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Regulation Of The Force Of Skeletal Muscle Contraction Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Osteoblast Differentiation Mitochondrial Prohibitin Complex Nucleus Cis-regulatory Region Sequence-specific DNA Binding Apoptotic Signaling Pathway Negative Regulation Of Cell Population Proliferation TEAD-YAP Complex Regulation Of Cytochrome-c Oxidase Activity Amide Binding Endopeptidase Complex Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Signal Transduction By P53 Class Mediator Lens Fiber Cell Apoptotic Process Lateral Mesoderm Development