KIF3A and KIF3B

Number of citations: 37 (PubMedID 7559760)
Data Source: HPRD (in vivo, in vitro)

		KIF3A	KIF3B
Name		kinesin family member 3A	kinesin family member 3B
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Kinesin II Complex Cell Projection Extracellular Exosome Ciliary Tip Axon Cytoplasm	Cytoplasm Centrosome Cytosol Cytoskeleton Kinesin Complex Plus-end Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Membrane Kinesin II Complex Axon Dendrite Midbody Dendrite Cytoplasm Cell Projection Dendritic Spine Synapse Extracellular Exosome Ciliary Tip Postsynapse Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Cytoskeletal Protein Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Protein Phosphatase Binding Spectrin Binding Small GTPase Binding Protein-containing Complex Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Small GTPase Binding Intraciliary Transport Particle B Binding
	Biological Process	Organelle Organization Microtubule-based Movement Anterograde Axonal Transport Centriole-centriole Cohesion Transport Along Microtubule Protein Transport Cell Projection Organization Microtubule Anchoring At Centrosome Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Cell Junction	Microtubule-based Movement Mitotic Spindle Organization Mitotic Centrosome Separation Determination Of Left/right Symmetry Axo-dendritic Transport Anterograde Axonal Transport Vesicle-mediated Transport Protein-containing Complex Localization Positive Regulation Of Cytokinesis Opsin Transport Intraciliary Transport Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Mitotic Spindle Assembly Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Hedgehog 'off' state Intraflagellar transport Activation of SMO Activation of SMO COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins	Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Asthma ( 31619474 31959851 ) Asthma (childhood onset) ( 31036433 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 22197932 23042114 25574825 26482879 ) Atopic march ( 26542096 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Mosquito bite size ( 28199695 ) Refractive error ( 32231278 )	Age at first sexual intercourse ( 27089180 34211149 ) Chronic obstructive pulmonary disease ( 28166215 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Inflammatory bowel disease ( 28067908 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 27863252 )
Interacting Genes		21 interacting genes: APP BTG3 DISC1 DSCAM DSCR9 GRB2 HUNK KIF3B KIF3C LIG4 MAP3K10 MAP3K11 MORC3 NEK1 NRIP1 PLEKHA5 PPP1R15A RPGR TRIM14 TULP3 VHL	12 interacting genes: APP IFT20 KIF3A KIFAP3 LMO2 LMO4 MAP3K10 MAP3K11 NEDD4L PRC1 RAB4A SASH1
Entrez ID		11127	9371
HPRD ID		05250	04781
Ensembl ID		ENSG00000131437	ENSG00000101350
Uniprot IDs		B4DHG8 E9PES4 J3KPF9 Q05CT3 Q9Y496	O15066
PDB IDs		Not available	3B6U
GO Terms Enriched among Interactors		Cilium Kinesin Complex JUN Kinase Kinase Kinase Activity Centrosome Positive Regulation Of JUN Kinase Activity Amyloid-beta Complex Positive Regulation Of Metabolic Process Axon Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Plasma Membrane Bounded Cell Projection Organization Central Nervous System Development Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Transport Along Microtubule Amylin Binding Positive Regulation Of JNK Cascade Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Amyloid Fibril Formation Microtubule-based Process Protein Serine/threonine Kinase Binding Cytoplasm Microtubule-based Movement Positive Regulation Of Axon Extension Guanyl-nucleotide Exchange Factor Adaptor Activity ATP Binding Microtubule Establishment Of Integrated Proviral Latency Positive Regulation Of MAP Kinase Activity Phosphorylation Peptidyl-serine Phosphorylation Protein Serine Kinase Activity Protein Phosphorylation Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Cilium Assembly Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Cilium Organization Ciliary Base Ovarian Follicle Rupture Neuron Recognition Ciliary Tip Molecular Adaptor Activity Intraciliary Transport Cell Projection Organization Cytoskeleton-dependent Intracellular Transport Acetylcholine Receptor Activator Activity PTB Domain Binding	Positive Regulation Of JUN Kinase Activity Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of MAP Kinase Activity Kinesin II Complex Spindle Microtubule Ciliary Tip Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Positive Regulation Of Protein Serine/threonine Kinase Activity Plus-end-directed Vesicle Transport Along Microtubule Plus-end-directed Organelle Transport Along Microtubule Plasma Membrane Bounded Cell Projection Organization Microtubule-based Transport Regulation Of MAP Kinase Activity JUN Kinase Kinase Kinase Activity Axo-dendritic Transport Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of JNK Cascade Cell Projection Organization Positive Regulation Of Catalytic Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Microtubule-based Movement MAP Kinase Kinase Kinase Activity Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation BHLH Transcription Factor Binding Positive Regulation Of MAPK Cascade Neuron Projection Development Kinesin Binding Photoreceptor Connecting Cilium Regulation Of Catalytic Activity Vesicle Transport Along Microtubule Kinesin Complex Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Receptor Localization To Synapse Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Microtubule Cytoskeleton