BTN3A1 and TFF1

Number of citations: 0 (PubMedID 21982860)
Data Source: BioGRID (pull down)

		BTN3A1	TFF1
Name		butyrophilin subfamily 3 member A1	trefoil factor 1
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Protein Binding	Protein Binding Growth Factor Activity
	Biological Process	Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Positive Regulation Of Type II Interferon Production Activated T Cell Proliferation T Cell Receptor Signaling Pathway	Carbohydrate Metabolic Process Signal Transduction Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Iron Ion Cell Differentiation Maintenance Of Gastrointestinal Epithelium Response To Immobilization Stress Response To Peptide Hormone
Pathways		Butyrophilin (BTN) family interactions	Estrogen-dependent gene expression
Drugs		None	Raloxifene Afimoxifene
GWAS		A body shape index ( 34021172 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Fish- and plant-related diet ( 32066663 ) General cognitive ability ( 29844566 ) Hemoglobin levels ( 32327693 ) Hip circumference adjusted for BMI ( 34021172 ) Intelligence (MTAG) ( 29326435 ) Lung cancer ( 28604730 ) Refractive error ( 32231278 ) Schizophrenia ( 19571809 ) Small cell lung carcinoma ( 28604730 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 32154731 ) Type 1 diabetes ( 31152121 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 )	Blood protein levels ( 30072576 ) Pancreatic cancer ( 22158540 )
Interacting Genes		2 interacting genes: ACE2 TFF1	20 interacting genes: AKT1 APC ATM BTN3A1 BTNL8 CD300LD ESR2 FCRL4 FGFR2 GKN2 MUC6 RAD51 SGTB SIGLEC8 TSG101 UBQLN1 UBQLN4 VSNL1 XRCC3 ZNF250
Entrez ID		11119	7031
HPRD ID		10693	00219
Ensembl ID		ENSG00000026950	ENSG00000160182
Uniprot IDs		A8K547 O00481	P04155
PDB IDs		4F80 4F9L 4F9P 4JKW 4K55 4N7I 4N7U 4V1P 5HM7 5LYG 5LYK 5ZXK 6ISM 6ITA 6J06 6XLQ 8DFX 8IXV 8IZE 8IZG 8JYC 8JYE	1HI7 1PS2 6V1D
GO Terms Enriched among Interactors		Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Entry Receptor-mediated Virion Attachment To Host Cell Viral Translation Viral Life Cycle Tryptophan Transport Positive Regulation Of Gap Junction Assembly Aromatic Amino Acid Transport Transporter Activator Activity Positive Regulation Of Cardiac Muscle Contraction Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Receptor-mediated Virion Attachment To Host Cell Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Regulation Of Gap Junction Assembly Virion Attachment To Host Cell Drinking Behavior Adhesion Of Symbiont To Host Positive Regulation Of Striated Muscle Contraction Endocytosis Involved In Viral Entry Into Host Cell Negative Regulation Of Cell Population Proliferation Positive Regulation Of Amino Acid Transport Response To Immobilization Stress Maintenance Of Gastrointestinal Epithelium Metallocarboxypeptidase Activity Regulation Of Cardiac Conduction Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Carboxypeptidase Activity Response To Iron Ion Maternal Process Involved In Female Pregnancy Epithelial Structure Maintenance Peptide Hormone Processing Positive Regulation Of Heart Contraction Signaling Receptor Ligand Precursor Processing Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Muscle Contraction Brush Border Membrane Ceramide Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Proliferation Extracellular Space System Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Vasoconstriction Digestive System Process Endocytic Vesicle Membrane Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Regulation Of Cardiac Muscle Contraction	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Regulation Of Macroautophagy Response To Alcohol Regulation Of Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance ATP-dependent DNA Damage Sensor Activity Telomere Maintenance Via Recombination Mitotic Recombination Regulation Of Sister Chromatid Segregation Cellular Response To Stress Cellular Response To Decreased Oxygen Levels Protein Autophosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Response To Stress Identical Protein Binding Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Chromosome Segregation Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Nuclear Division Regulation Of Mitotic Nuclear Division Response To X-ray Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Recombinational Repair Autophagy Reciprocal Meiotic Recombination Telomere Organization Regulation Of DNA Recombination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Immune Response-activating Signaling Pathway Cellular Response To Oxygen Levels Negative Regulation Of Macroautophagy Regulation Of Protein Catabolic Process Regulation Of Autophagy Macroautophagy Homologous Recombination Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Macromolecule Catabolic Process Regulation Of TRNA Methylation Negative Regulation Of Mitotic Nuclear Division Meiosis I