EMILIN1 and EMILIN2

Number of citations: 0 (PubMedID 11278945)
Data Source: HPRD (two hybrid)

		EMILIN1	EMILIN2
Name		elastin microfibril interfacer 1	elastin microfibril interfacer 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Extracellular Matrix Integrin Alpha4-beta1 Complex Extracellular Exosome EMILIN Complex	Extracellular Region Collagen Trimer Extracellular Matrix EMILIN Complex
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Molecular Adaptor Activity Integrin Binding Involved In Cell-matrix Adhesion	Protein Binding Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Aortic Valve Morphogenesis Cell Adhesion Cell-matrix Adhesion Regulation Of Blood Pressure Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Cell Adhesion Mediated By Integrin Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Elastic Fiber Assembly Negative Regulation Of Cell Activation Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Platelet Aggregation Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Macrophage Migration	Cell Adhesion Regulation Of Blood Pressure Positive Regulation Of Blood Coagulation Negative Regulation Of Cell Migration Cell Adhesion Mediated By Integrin Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Platelet Aggregation
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Molecules associated with elastic fibres Molecules associated with elastic fibres
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	A body shape index ( 34021172 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Triglyceride levels ( 32203549 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: EPHB4	None recorded
Interacting Genes		28 interacting genes: ABI3 BEX3 BEX5 BFSP1 CDCA8 CENPQ COG7 DYNC1I1 EMILIN2 FBXO28 GNG13 IFT20 LAIR2 LRRIQ1 MIA2 MTMR9 NECAB2 NMI PLAC9 PRKAA2 RABGEF1 RIBC1 SNAPC5 TAB2 TSNAX YJU2 ZC2HC1C ZNF655	1 interacting genes: EMILIN1
Entrez ID		11117	84034
HPRD ID		00563	09937
Ensembl ID		ENSG00000138080	ENSG00000132205
Uniprot IDs		Q9Y6C2	Q9BXX0
PDB IDs		2KA3 2OII	Not available
GO Terms Enriched among Interactors		A2A Adenosine Receptor Binding	EMILIN Complex Integrin Alpha4-beta1 Complex Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Collagen Biosynthetic Process Integrin Binding Involved In Cell-matrix Adhesion Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Bacterium Positive Regulation Of Defense Response To Bacterium Regulation Of Collagen Fibril Organization Negative Regulation Of Macrophage Migration Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Platelet Aggregation Positive Regulation Of Extracellular Matrix Assembly Extracellular Matrix Constituent Conferring Elasticity Elastic Fiber Assembly Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Coagulation Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Regulation Of Platelet Aggregation Negative Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Blood Coagulation Cell Adhesion Mediated By Integrin Extracellular Matrix Assembly Aortic Valve Morphogenesis Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Mononuclear Cell Migration Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Macrophage Migration Negative Regulation Of Leukocyte Migration Regulation Of Platelet Activation Heart Valve Morphogenesis Positive Regulation Of Wound Healing Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of SMAD Protein Signal Transduction Regulation Of Extracellular Matrix Organization Collagen Trimer Regulation Of Hemostasis Regulation Of Blood Coagulation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell-matrix Adhesion Extracellular Matrix Structural Constituent Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell-substrate Adhesion Regulation Of Wound Healing Negative Regulation Of Vasculature Development