KRR1 and SRPK1

Number of citations: 104 (PubMedID 32707033)
Data Source: BioGRID (affinity chromatography technology, enzymatic study)

		KRR1	SRPK1
Name		KRR1 small subunit processome component	SRSF protein kinase 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Membrane Small-subunit Processome Intercellular Bridge Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Nuclear Matrix Nuclear Speck
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis	Spliceosomal Complex Assembly MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Cell Differentiation Sperm DNA Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Maturation of nucleoprotein Replacement of protamines by nucleosomes in the male pronucleus
GWAS		Atrial fibrillation ( 29892015 ) Blood trace element (Cu levels) ( 23720494 ) Blood urea nitrogen levels ( 29403010 ) Creatinine levels ( 29403010 ) Daytime sleep phenotypes ( 27126917 ) Estimated glomerular filtration rate ( 30604766 ) Glomerular filtration rate ( 29403010 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Polycystic ovary syndrome ( 26416764 30566500 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 )	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 )
Interacting Genes		4 interacting genes: EWSR1 OGT RPS14 SRPK1	167 interacting genes: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARK2N ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf87 C16orf78 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CIMAP1D CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG JHY KCNAB1 KCNN2 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L3 MACROH2A1 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MAPT MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBMS2 RIMS4 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SANBR SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRRM1 SRSF1 SRSF10 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP7 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2
Entrez ID		11103	6732
HPRD ID		11027	15992
Ensembl ID		ENSG00000111615	ENSG00000096063
Uniprot IDs		Q13601	Q96SB4
PDB IDs		7MQ8 7MQ9	1WAK 1WBP 3BEG 4WUA 5MXX 5MY8 5NNG 5XV7 6FAD 7DD1 7PQS 7ZKS
GO Terms Enriched among Interactors		Protein-containing Complex Organization Protein-containing Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cytoplasmic Translation Protein-RNA Complex Assembly Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Cone Retinal Bipolar Cell Differentiation Retinal Cone Cell Differentiation Carbon Catabolite Regulation Of Transcription Regulation Of Transcription By Glucose Retinal Bipolar Neuron Differentiation Retinal Rod Cell Differentiation	RNA Splicing Regulation Of MRNA Processing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Nucleoplasm Nucleus MRNA Binding Nuclear Speck Nucleic Acid Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleic Acid Binding Protein Kinase Activity Negative Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Kinase Activity Negative Regulation Of RNA Splicing Spliceosomal Complex Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Protein-RNA Complex Assembly Pre-mRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Alternative MRNA Splicing, Via Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific MRNA Binding Main Axon Response To Starvation Regulation Of Toll Signaling Pathway Catalytic Step 2 Spliceosome Protein Autophosphorylation IkappaB Kinase Complex Positive Regulation Of Viral Process Protein Phosphorylation Positive Regulation Of RNA Splicing