CHD3 and C4orf17

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		CHD3	C4orf17
Name		chromodomain helicase DNA binding protein 3	chromosome 4 open reading frame 17
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytoskeleton NuRD Complex PML Body Centriolar Satellite	None
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding Metal Ion Binding ATP-dependent Chromatin Remodeler Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Spindle Organization Centrosome Cycle Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation	None
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	None
GWAS		Ischemic stroke ( 26089329 ) Macular thickness ( 30535121 ) Prostate cancer ( 29892016 ) Refractive error ( 32231278 ) Stroke ( 26089329 )	Alanine aminotransferase levels ( 33547301 ) Alcohol consumption (drinks per week) ( 30643258 ) Celiac disease ( 23936387 ) Eating disorders ( 23568457 ) Metabolite levels (MHPG) ( 23319000 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Regular attendance at a pub or social club ( 29970889 ) Severe malaria ( 29381699 ) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699 )
Interacting Genes		101 interacting genes: ACTR1B ADH5 AIMP2 ATP5IF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CBX4 CPE CRCT1 CREB1 CREBBP CSTF2 CTBP1 CTTN ENTR1 ETV5 FABP4 FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B HABP4 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MX1 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RETREG2 RGS2 RIF1 RNF10 RPL29 SAFB SAT1 SATB1 SERBP1 SERF2 SETX SGSM2 SIRT6 SKIL SLC27A6 SPOP SRRT STIP1 SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TRIM54 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBC UBE2I UROD VIM XRCC4 YAE1 ZHX1	14 interacting genes: ABI2 CHD3 COPS6 CRK GRN HOMER3 KDM1A LONRF1 NCK2 PRMT1 SH3GL3 SUV39H1 TUBA4A ZNF417
Entrez ID		1107	84103
HPRD ID		09071	12825
Ensembl ID		ENSG00000170004	ENSG00000138813
Uniprot IDs		A0A8V8TR54 B3KWV4 Q12873 Q2TAZ1	Q53FE4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Nucleoplasm Nucleus Negative Regulation Of Transcription By RNA Polymerase II Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process SUMO Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process PML Body Protein Sumoylation Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Programmed Cell Death RNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Ubiquitin Protein Ligase Binding Regulation Of Cell Development Presynaptic Cytosol Postsynaptic Cytosol Enzyme Binding Positive Regulation Of Metabolic Process Nucleic Acid Metabolic Process Nuclear Speck Regulation Of Neurogenesis Macromolecule Metabolic Process DNA Repair Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gliogenesis Protein-containing Complex Regulation Of Proteolysis Positive Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Stress Regulation Of Cell Differentiation Transcription Corepressor Activity Promoter-specific Chromatin Binding	Signaling Adaptor Activity Regulation Of Cellular Response To Stress Regulation Of Developmental Process Enzyme Binding Blastocyst Hatching Cytoskeletal Anchor Activity Signaling Receptor Complex Adaptor Activity Regulation Of Neuron Projection Development Histone Methyltransferase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Positive Regulation Of Aspartic-type Peptidase Activity GATOR1 Complex Binding Regulation Of DNA Repair Chromatin Remodeling Negative Regulation Of Biosynthetic Process Helper T Cell Diapedesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphorylated Amino Acid Binding Receptor Tyrosine Kinase Binding Scaffold Protein Binding Response To Cholecystokinin Positive Regulation Of Trophectodermal Cell Proliferation Zonula Adherens Assembly Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Cell Projection Organization Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Kinase Binding SH3 Domain Binding Regulation Of Actin Cytoskeleton Organization Cerebral Cortex Development Regulation Of Actin Filament-based Process Cerebellar Neuron Development Negative Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Microglial Cell Activation Involved In Immune Response Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Lysosome Organization Astrocyte Activation Involved In Immune Response Positive Regulation Of Inflammatory Response To Wounding Trophectodermal Cell Proliferation