RAPGEF4 and BMERB1

Number of citations: 69 (PubMedID 24722188)
Data Source: BioGRID (two hybrid, two hybrid)

		RAPGEF4	BMERB1
Name		Rap guanine nucleotide exchange factor 4	bMERB domain containing 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse	Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Protein-macromolecule Adaptor Activity Small GTPase Binding	Protein Binding
	Biological Process	Adaptive Immune Response Exocytosis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Hormone Secretion Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle	Microtubule Depolymerization Negative Regulation Of Microtubule Depolymerization Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration
Pathways		Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion	None
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Fasting blood glucose ( 33842983 ) Fasting plasma glucose ( 25187374 ) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273 ) HDL cholesterol levels ( 32203549 ) Hippocampal volume ( 25625606 ) Lateral ventricle temporal horn volume ( 31530798 )	Creutzfeldt-Jakob disease (sporadic) ( 32949544 )
Interacting Genes		14 interacting genes: ATXN1 BMERB1 DEF6 DSCAM LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A	4 interacting genes: ENO2 RAPGEF4 TCF12 UBC
Entrez ID		11069	89927
HPRD ID		06929	12382
Ensembl ID		ENSG00000091428	ENSG00000166780
Uniprot IDs		B7Z278 E9PB94 Q8WZA2 X5D7N4	Q96MC5
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Vesicle Exocytosis Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission GDP Binding Rap Protein Signal Transduction Regulation Of Cell Communication Regulation Of Protein Depolymerization Regulation Of Signaling Small GTPase-mediated Signal Transduction Cellular Localization GTPase Activity Regulation Of Locomotion Regulation Of Protein-containing Complex Disassembly Regulation Of Regulated Secretory Pathway Regulation Of Glial Cell Migration GTP Binding Cell Projection Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Regulation Of Biological Quality Regulation Of Microtubule Depolymerization Regulation Of Exocytosis Intracellular Signaling Cassette Locomotory Behavior Post-embryonic Retina Morphogenesis In Camera-type Eye Positive Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Locomotion Cell Projection Morphogenesis Netrin Receptor Binding Positive Regulation Of Phosphorylation Social Behavior Neuron Projection Morphogenesis Synapse Synapse Organization Tubulin Binding Retrograde Axonal Protein Transport Primary Dendrite Establishment Of Localization In Cell Neuron Cellular Homeostasis Regulation Of Signal Transduction Small GTPase Binding Response To Antineoplastic Agent Guanyl-nucleotide Exchange Factor Activity Regulation Of MAPK Cascade Regulation Of Secretion Regulation Of Secretion By Cell G Protein Activity Nuclear Transport	None