TMED1 and IL1RL1

Number of citations: 0 (PubMedID 8621446)
Data Source: HPRD (in vivo)

		TMED1	IL1RL1
Name		transmembrane p24 trafficking protein 1	interleukin 1 receptor like 1
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Extracellular Region Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Protein Binding Hydrolase Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Immune System Process Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Signal Transduction Cell-cell Signaling Protein Transport Innate Immune Response	Negative Regulation Of T-helper 1 Type Immune Response Inflammatory Response Immune Response Signal Transduction Response To Wounding Macrophage Differentiation Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Inflammatory Response
Pathways		None	PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling
GWAS		No GWAS studies recorded	Adult asthma ( 30578877 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Allergic rhinitis ( 30013184 31361310 ) Allergic sensitization ( 30013184 23817571 ) Allergy ( 27182965 ) Asthma ( 27182965 30929738 29273806 26620591 31361310 31619474 34103634 21804549 23028483 32296059 31959851 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 29273806 31036433 ) Asthma (moderate or severe) ( 30552067 ) Asthma (time to onset) ( 27130862 ) Asthma and hay fever ( 24388013 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 26482879 23042114 ) Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Celiac disease ( 18311140 20190752 ) Childhood asthma with severe exacerbations ( 33328473 ) Crohn's disease ( 21102463 28067908 ) Delirium ( 29631748 ) Eosinophil count ( 29403010 32888494 19198610 ) Eosinophil percentage of white cells ( 32888494 ) FEV1 ( 30804560 ) Inflammatory bowel disease ( 28067908 23128233 ) Lung function (FEV1/FVC) ( 30804560 ) Nasal polyps ( 30643255 ) Neutrophil percentage of white cells ( 32888494 ) Primary biliary cholangitis ( 26394269 ) Self-reported allergy ( 23817569 ) Serum protein levels (sST2) ( 23999434 ) Waist circumference ( 23966867 )
Interacting Genes		6 interacting genes: F2RL1 GPR37 IL1RL1 LTB4R2 SEC23B SMAD3	18 interacting genes: APP ASGR2 CLEC12B CLEC2D CLEC7A CREB3L1 GPR152 GPR42 HRAS IL33 MCFD2 MYD88 SIGLEC12 SLC38A1 TIRAP TMED1 TSPAN18 YIPF6
Entrez ID		11018	9173
HPRD ID		05653	03123
Ensembl ID		ENSG00000099203	ENSG00000115602
Uniprot IDs		Q13445	Q01638
PDB IDs		7RRM	4KC3
GO Terms Enriched among Interactors		Positive Regulation Of Positive Chemotaxis Proteinase-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Regulation Of Interleukin-1 Production Regulation Of Type II Interferon Production Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium G Protein-coupled Receptor Activity Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Interleukin-1 Beta Production Neuropeptide Signaling Pathway Prosaposin Receptor Activity G Protein-coupled Peptide Receptor Activity Sterol Response Element Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Ameboidal-type Cell Migration Paraxial Mesoderm Morphogenesis Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Interleukin-33 Binding Interleukin-33 Receptor Activity Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Regulation Of Wound Healing Positive Regulation Of Chemotaxis Myeloid Leukocyte Differentiation Positive Regulation Of Killing Of Cells Of Another Organism Regulation Of Lung Blood Pressure Leukotriene Signaling Pathway Cell-cell Junction Organization Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cytoskeleton Organization Mature Conventional Dendritic Cell Differentiation Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Signal Transduction Regulation Of Response To Wounding Regulation Of Blood Pressure Thrombin-activated Receptor Activity Positive Regulation Of Dopamine Metabolic Process Pericardium Development Mesoderm Morphogenesis	Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Carbohydrate Binding Vesicle-mediated Transport Defense Response To Protozoan Positive Regulation Of JNK Cascade Response To Protozoan Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Type II Interferon Production Response To Molecule Of Fungal Origin Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response To Other Organism Positive Regulation Of Cytokine Production Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of JNK Cascade Positive Regulation Of Interleukin-23 Production Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Plasma Membrane Regulation Of Interleukin-23 Production Innate Immune Response Regulation Of Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Interleukin-1 Production Defense Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type II Interferon Production Immune Response-regulating Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Regulation Of Leukocyte Migration Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Innate Immune Response Response To Yeast Positive Regulation Of MAPK Cascade Positive Regulation Of Defense Response Regulation Of Interleukin-8 Production Defense Response To Symbiont MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress