SLC38A3 and HMGN1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SLC38A3	HMGN1
Name		solute carrier family 38 member 3	high mobility group nucleosome binding domain 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane	Chromatin Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm
	Molecular Function	L-histidine Transmembrane Transporter Activity Neutral L-amino Acid:sodium Symporter Activity Amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-asparagine Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity Symporter Activity Antiporter Activity L-glutamine, Sodium:proton Antiporter Activity L-asparagine, Sodium:proton Antiporter Activity L-histidine, Sodium:proton Antiporter Activity	DNA Binding Chromatin Binding Protein Binding Nucleosomal DNA Binding
	Biological Process	Amino Acid Transmembrane Transport Monoatomic Ion Transport Sodium Ion Transport Amino Acid Transport Asparagine Transport Glutamine Transport Female Pregnancy Glutamine Secretion L-alanine Transport Histidine Transport Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Potassium Ion Starvation Intracellular Amino Acid Homeostasis Transport Across Blood-brain Barrier L-histidine Transport L-glutamine Import Across Plasma Membrane L-histidine Import Across Plasma Membrane L-asparagine Import Across Plasma Membrane Positive Regulation Of Glutamine Transport	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation
Pathways		Amino acid transport across the plasma membrane	None
Drugs		Histidine Asparagine	None
GWAS		Body mass index ( 26426971 ) Conotruncal heart defects (maternal effects) ( 28468790 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Immature fraction of reticulocytes ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Sleep duration (short sleep) ( 30846698 ) Smoking status (ever vs never smokers) ( 30643258 )	LDL cholesterol levels ( 32203549 ) Lipoprotein (a) levels ( 33730874 ) Smoking status (ever vs never smokers) ( 30643258 )
Interacting Genes		3 interacting genes: COL6A2 HMGN1 SETDB1	22 interacting genes: CDC42 CEBPA CHEK2 EP300 GSK3A HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ
Entrez ID		10991	3150
HPRD ID		11980	01231
Ensembl ID		ENSG00000188338	ENSG00000205581
Uniprot IDs		Q99624	P05114 Q6NSG7
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Collagen Type VI Trimer Response To Radiation Response To Light Stimulus Response To UV Pyrimidine Dimer Repair Regulation Of Development, Heterochronic Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Female Germ Cell Nucleus Post-embryonic Camera-type Eye Morphogenesis Response To UV-C Post-embryonic Eye Morphogenesis T Cell Chemotaxis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Myoblast Fusion Heterochromatin Organization Histone H3K9 Trimethyltransferase Activity Histone H3K9 Monomethyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Methyltransferase Activity Chromatin Binding Response To UV-B Positive Regulation Of Lymphocyte Chemotaxis Regulation Of Myoblast Fusion Regulation Of Lymphocyte Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Histone H3 Methyltransferase Activity Transposable Element Silencing By Heterochromatin Formation	TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process TOR Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Steroid Hormone Protein Serine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Protein Domain Specific Binding Cellular Response To Stress Regulation Of DNA-templated Transcription Response To Gamma Radiation Regulation Of RNA Biosynthetic Process Cellular Response To Lithium Ion Regulation Of Gene Expression Protein Serine/threonine Kinase Activity Regulation Of Metabolic Process Response To Lithium Ion Chromatin Organization Histone H3S28 Kinase Activity Response To Hormone Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Radiation Chromosome, Telomeric Region Nucleus Negative Regulation Of Biosynthetic Process Protein Kinase Activity Protein Modification Process Protein Phosphorylation