COPS6 and CHRNB1

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		COPS6	CHRNB1
Name		COP9 signalosome subunit 6	cholinergic receptor nicotinic beta 1 subunit
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Postsynaptic Specialization Membrane
	Molecular Function	Protein Binding Peptidase Activity Metal-dependent Deubiquitinase Activity	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Channel Activity Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation	Postsynaptic Membrane Organization Skeletal Muscle Contraction Monoatomic Ion Transport Monoatomic Cation Transport Muscle Contraction Signal Transduction Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Monoatomic Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Membrane Potential Nervous System Process Membrane Depolarization Muscle Cell Development Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	None
Diseases		None	Congenital myasthenic syndrome
GWAS		Brain morphology (MOSTest) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Brain morphology (MOSTest) ( 32665545 ) Emotional recognition ( 31596458 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		95 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CRIPTO CUL1 CUL5 DIS3L2 DLEU1 DSP EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHANK3 SHC3 SLC2A1 SMN1 SNRPG STAMBPL1 STK40 STX5 SULT1E1 TK1 TP53 TP63 TRDMT1 TRIB3 UBC USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24	3 interacting genes: ASB6 COPS6 RAPSN
Entrez ID		10980	1140
HPRD ID		16735	01156
Ensembl ID		ENSG00000168090	ENSG00000170175
Uniprot IDs		Q7L5N1	P11230
PDB IDs		4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F	Not available
GO Terms Enriched among Interactors		Protein Neddylation Protein Deneddylation Regulation Of Protein Neddylation Nucleoplasm Heart Development COP9 Signalosome Developmental Process Cytosol Cellular Response To Staurosporine Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Protein Binding Positive Regulation Of Neuron Apoptotic Process Protease Binding Pyroptotic Inflammatory Response Protein Modification By Small Protein Removal Nucleus Animal Organ Development Regulation Of Cell Cycle G1/S Phase Transition Cytoplasm Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Developmental Process Cell Differentiation Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Keratinocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Scaffold Protein Binding MAPK Cascade Cellular Response To Alkaloid Regulation Of Protein Modification Process Positive Regulation Of Programmed Cell Death Post-translational Protein Modification Protein Modification Process Regulation Of Post-translational Protein Modification Protein Tag Activity Cullin-RING Ubiquitin Ligase Complex Protein-containing Complex Cellular Response To Starvation Response To Nutrient Levels Mitotic G1 DNA Damage Checkpoint Signaling Rhythmic Synaptic Transmission G1/S Transition Of Mitotic Cell Cycle Mitotic G1/S Transition Checkpoint Signaling	Structural Constituent Of Postsynaptic Specialization Positive Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Neuromuscular Synaptic Transmission Regulation Of Postsynaptic Membrane Organization Regulation Of Motor Neuron Apoptotic Process Skeletal Muscle Acetylcholine-gated Channel Clustering Maintenance Of Postsynaptic Specialization Structure Establishment Of Protein Localization To Postsynaptic Membrane Motor Neuron Apoptotic Process Acetylcholine Receptor Binding Protein Deneddylation Metal-dependent Deubiquitinase Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Density Organization Regulation Of Protein Neddylation Protein Neddylation Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Postsynaptic Specialization Organization Maintenance Of Synapse Structure Synaptic Transmission, Cholinergic Ionotropic Glutamate Receptor Binding Postsynaptic Specialization Membrane Protein-membrane Adaptor Activity COP9 Signalosome Protein Modification By Small Protein Conjugation Neuromuscular Junction Development Post-translational Protein Modification Receptor Clustering Receptor Localization To Synapse Cell Junction Maintenance Protein Localization To Synapse Cellular Component Maintenance Positive Regulation Of Neuron Apoptotic Process Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Protein Localization To Cell Junction