YWHAQ and CDC25B

Number of citations: 0 (PubMedID 10713667)
Data Source: HPRD (in vitro, in vivo)

		YWHAQ	CDC25B
Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	cell division cycle 25B
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton
	Molecular Function	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Protein Phosphorylation Female Meiosis I Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cytokinesis Positive Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways	Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs		Phenethyl Isothiocyanate	L-cysteic acid
GWAS		Heart rate variability traits ( 22174390 ) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933 )	Basophil percentage of granulocytes ( 27863252 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) SAPHO syndrome ( 33816493 )
Interacting Genes		216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2	28 interacting genes: AATK AR AURKA BRSK1 BRSK2 CDC14A CDK1 CDK2 CDK5 CHEK1 CREBBP CSNK2A1 CSNK2B ESR1 FHL3 KAT2B MAPK14 MAPK9 MAPKAPK2 MELK PGR PSME3 SFN YWHAB YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		10971	994
HPRD ID		00886	00307
Ensembl ID		ENSG00000134308	ENSG00000101224
Uniprot IDs		P27348	B3KS38 B4DIG0 B4DQZ3 B4DRC3 E1YMX4 G8JLH2 P30305
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH	1CWR 1CWS 1CWT 1QB0 1YM9 1YMD 1YMK 1YML 1YS0 2A2K 2IFD 2IFV 2UZQ 3FQT 3FQU 4WH7 4WH9
GO Terms Enriched among Interactors		Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Intracellular Signal Transduction G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Kinase Activity Protein Phosphorylation Phosphoserine Residue Binding Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Protein Domain Specific Binding Regulation Of Cell Cycle Regulation Of Intracellular Protein Transport Mitotic Cell Cycle Phase Transition Rhythmic Process Cell Cycle Phase Transition Regulation Of Cell Cycle Process Transferase Activity DNA Damage Checkpoint Signaling Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Nucleocytoplasmic Transport Signal Transduction Cytosol Intracellular Signaling Cassette Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle MAPK Cascade ATP Binding Signal Transduction In Response To DNA Damage Nucleus Regulation Of Intracellular Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Cell Communication Regulation Of Primary Metabolic Process Regulation Of Signaling Protein Modification Process Nucleoplasm Centrosome Estrogen Response Element Binding Protein Sequestering Activity Negative Regulation Of RNA Metabolic Process Apoptotic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process