YWHAQ and KCNK9

Number of citations: 40 (PubMedID 12433946)
Data Source: HPRD (in vivo, two hybrid)

		YWHAQ	KCNK9
Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	potassium two pore domain channel subfamily K member 9
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Plasma Membrane Synaptic Vesicle Membrane Dendrite Cell Projection
	Molecular Function	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding	Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Visual Perception Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Resting Membrane Potential Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Regulation Of Action Potential Firing Rate Potassium Ion Import Across Plasma Membrane Negative Regulation Of Aldosterone Secretion
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways	TWIK-releated acid-sensitive K+ channel (TASK) Phase 4 - resting membrane potential
Drugs		Phenethyl Isothiocyanate	Doxapram Halothane
Diseases		None	Birk Barel mental retardation syndrome (BBMRS); Birk-Barel syndrome (BIBAS)
GWAS		Heart rate variability traits ( 22174390 ) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933 )	Adiponectin levels ( 21700879 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872 ) Cerebrospinal T-tau levels ( 26252872 ) Circulating phylloquinone levels ( 25411281 ) Low density lipoprotein cholesterol levels ( 30498476 ) Menarche (age at onset) ( 25231870 ) Response to lurasidone in schizophrenia ( 29730043 ) Urate levels in overweight individuals ( 25811787 ) Visceral adipose tissue ( 26480920 )
Interacting Genes		216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2	7 interacting genes: SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		10971	51305
HPRD ID		00886	16167
Ensembl ID		ENSG00000134308	ENSG00000169427
Uniprot IDs		P27348	Q9NPC2
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH	3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3UX0 4FR3 6GHP 8K1J 8K1Q 8K1V 8K1Z 9G9V 9G9W
GO Terms Enriched among Interactors		Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus	Phosphoserine Residue Binding Protein Sequestering Activity Protein Domain Specific Binding Protein Targeting Establishment Of Protein Localization Intracellular Protein Localization Identical Protein Binding Transmembrane Transporter Binding Focal Adhesion Extracellular Exosome Phosphoprotein Binding Protein Kinase C Inhibitor Activity Substantia Nigra Development Neural Nucleus Development Cadherin Binding Melanosome Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Nucleocytoplasmic Transport Insulin-like Growth Factor Receptor Binding Regulation Of Intracellular Protein Transport Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Immune System Process Signal Transduction Negative Regulation Of Immune Response Negative Regulation Of Protein Localization Regulation Of Protein Export From Nucleus Regulation Of Transport Regulation Of Intracellular Transport Protein Phosphatase Inhibitor Activity Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Intracellular Signaling Cassette Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Immune Response Cytosol TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of Protein Kinase Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Enzyme Binding Glucocorticoid Catabolic Process Negative Regulation Of Kinase Activity Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport TOR Signaling Regulation Of Protein Transport Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Innate Immune Response Positive Regulation Of Intracellular Protein Transport