POP4 and POP1

Number of citations: 37 (PubMedID 15096576)
Data Source: HPRD (in vitro)

		POP4	POP1
Name		POP4 ribonuclease P/MRP subunit	POP1 ribonuclease P/MRP subunit
Structure
GO Annotations	Cellular Component	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolus Ribonuclease P Complex Multimeric Ribonuclease P Complex	Ribonuclease MRP Complex Extracellular Space Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Multimeric Ribonuclease P Complex
	Molecular Function	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	TRNA 5'-leader Removal RRNA Processing RNA Processing TRNA Processing	TRNA 5'-leader Removal TRNA Processing TRNA Decay
Pathways		tRNA processing in the nucleus	tRNA processing in the nucleus
GWAS		Body mass index ( 26426971 ) Heart rate increase in response to exercise ( 29497042 ) Heart rate response to exercise ( 29769521 ) Heart rate response to recovery post exercise (40 sec) ( 29497042 ) Heart rate response to recovery post exercise (50 sec) ( 29497042 ) Metabolite levels ( 23823483 )	Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292 )
Interacting Genes		7 interacting genes: AKT1 POP1 POP5 RPP14 RPP25 RPP30 RPP38	10 interacting genes: POP4 POP5 PTEN PYCARD RPP25 RPP30 RPP38 RPP40 USP7 WEE2-AS1
Entrez ID		10775	10940
HPRD ID		09358	03923
Ensembl ID		ENSG00000105171	ENSG00000104356
Uniprot IDs		O95707	Q96F88 Q99575
PDB IDs		6AHR 6AHU	6AHR 6AHU
GO Terms Enriched among Interactors		Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Ribonuclease MRP Complex TRNA Processing TRNA Metabolic Process Nucleolar Ribonuclease P Complex RNA Processing RNA Metabolic Process Nucleolus Nucleic Acid Metabolic Process RRNA Processing Ribonuclease P Complex RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Binding Nucleoplasm Macromolecule Metabolic Process Regulation Of TRNA Methylation Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Nucleus Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Endoribonuclease Complex Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Fatty Acid Beta-oxidation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion Response To Rapamycin Nitric-oxide Synthase Regulator Activity Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity RNA (guanine-N7)-methylation Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development	Ribonuclease MRP Complex Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Nucleolar Ribonuclease P Complex TRNA Processing TRNA Metabolic Process Ribonuclease P Complex RRNA Processing RRNA Metabolic Process Nucleolus RNA Processing Nucleoplasm Nucleic Acid Metabolic Process RNA Metabolic Process RNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Ribonuclease MRP Activity Myosin I Binding Regulation Of Protein Stability Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Macromolecule Metabolic Process Nucleus Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity NLRP6 Inflammasome Complex Pyrin Domain Binding Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II PML Body Central Nervous System Myelin Maintenance Negative Regulation Of Protein Phosphorylation Rhythmic Synaptic Transmission Symbiont-mediated Disruption Of Host Cell PML Body AIM2 Inflammasome Complex Myeloid Dendritic Cell Activation Involved In Immune Response Negative Regulation Of Phosphorylation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Pre-mRNA 5'-splice Site Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Synaptic Vesicle Clustering Regulation Of Establishment Of Protein Localization To Telomere NLRP1 Inflammasome Complex Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Metabolic Process