POP4 and RPP30

Number of citations: 73 (PubMedID 35831314)
Data Source: BioGRID (biochemical), HPRD (two hybrid)

		POP4	RPP30
Name		POP4 ribonuclease P/MRP subunit	ribonuclease P/MRP subunit p30
Structure
GO Annotations	Cellular Component	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolus Ribonuclease P Complex Multimeric Ribonuclease P Complex	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Multimeric Ribonuclease P Complex
	Molecular Function	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	TRNA 5'-leader Removal RRNA Processing RNA Processing TRNA Processing	TRNA 5'-leader Removal RRNA Processing TRNA Processing
Pathways		tRNA processing in the nucleus	tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol
GWAS		Body mass index ( 26426971 ) Heart rate increase in response to exercise ( 29497042 ) Heart rate response to exercise ( 29769521 ) Heart rate response to recovery post exercise (40 sec) ( 29497042 ) Heart rate response to recovery post exercise (50 sec) ( 29497042 ) Metabolite levels ( 23823483 )	Economic and political preferences (time) ( 22566634 ) Metabolite levels ( 23823483 )
Interacting Genes		7 interacting genes: AKT1 POP1 POP5 RPP14 RPP25 RPP30 RPP38	14 interacting genes: CEBPA HMG20A KHDRBS2 MAST1 POP1 POP4 PTEN RNF32 RPP14 RPP21 RPP38 RPP40 UBC WEE2-AS1
Entrez ID		10775	10556
HPRD ID		09358	09359
Ensembl ID		ENSG00000105171	ENSG00000148688
Uniprot IDs		O95707	P78346
PDB IDs		6AHR 6AHU	6AHR 6AHU
GO Terms Enriched among Interactors		Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Ribonuclease MRP Complex TRNA Processing TRNA Metabolic Process Nucleolar Ribonuclease P Complex RNA Processing RNA Metabolic Process Nucleolus Nucleic Acid Metabolic Process RRNA Processing Ribonuclease P Complex RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Binding Nucleoplasm Macromolecule Metabolic Process Regulation Of TRNA Methylation Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Nucleus Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Endoribonuclease Complex Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Fatty Acid Beta-oxidation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion Response To Rapamycin Nitric-oxide Synthase Regulator Activity Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity RNA (guanine-N7)-methylation Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development	Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Nucleolar Ribonuclease P Complex Ribonuclease MRP Complex TRNA Processing Ribonuclease P Complex TRNA Metabolic Process RNA Processing Endoribonuclease Complex Nucleolus RNA Metabolic Process RNA Binding Nucleic Acid Metabolic Process Nucleoplasm Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process RRNA Processing RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Ribonuclease MRP Activity RRNA Metabolic Process Response To Vitamin B2 C/EBP Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity