CFL2 and CAP2

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		CFL2	CAP2
Name		cofilin 2	cyclase associated actin cytoskeleton regulatory protein 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytoskeleton Actin Cytoskeleton Nuclear Matrix Z Disc I Band Extracellular Exosome	Cytoplasm Plasma Membrane Postsynaptic Density Membrane
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Actin Binding Protein Binding Adenylate Cyclase Binding Identical Protein Binding
	Biological Process	Actin Filament Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Sarcomere Organization Muscle Cell Cellular Homeostasis Actin Filament Severing	Cell Morphogenesis Cytoskeleton Organization Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity CAMP-mediated Signaling Presynaptic Actin Cytoskeleton Organization
Pathways		None	Role of ABL in ROBO-SLIT signaling
Diseases		Nemaline myopathy	None
GWAS		Alanine aminotransferase levels ( 33547301 34315874 ) Aspartate aminotransferase levels ( 33547301 34315874 ) Atrial fibrillation ( 29892015 30061737 ) Hip circumference adjusted for BMI ( 28552196 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Takayasu arteritis ( 33308445 )	Haemorrhoidal disease ( 33888516 ) Height ( 18391951 ) Mitochondrial DNA levels ( 25240745 ) QT interval ( 29213071 ) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834 )
Interacting Genes		12 interacting genes: ACTB ACTG1 CAP2 LIMK1 PDE4B POT1 RAB2A RNF4 SSH1 STK11 TRIM7 UBE2I	11 interacting genes: ACTG1 ADO ALAS1 CAP1 CFL2 DNM1L DSCAM GRXCR1 MT1P3 PRPF40A YWHAE
Entrez ID		1073	10486
HPRD ID		03262	10808
Ensembl ID		ENSG00000165410	ENSG00000112186
Uniprot IDs		Q549N0 Q9Y281	B7Z385 E9PDI2 P40123
PDB IDs		7M0G 7U8K	Not available
GO Terms Enriched among Interactors		Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Filament-based Process Regulation Of Transepithelial Transport Actin Cytoskeleton Organization Dense Body Morphogenesis Of A Polarized Epithelium Schaffer Collateral - CA1 Synapse Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Apical Junction Complex NuA4 Histone Acetyltransferase Complex Axonogenesis Regulation Of Synaptic Vesicle Endocytosis Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Recycling Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament-based Process Immune Response-regulating Signaling Pathway Maintenance Of Blood-brain Barrier Anatomical Structure Homeostasis Tissue Homeostasis Lamellipodium Multicellular Organismal-level Homeostasis Cytoplasm Cytoskeleton Organization Platelet Aggregation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Regulation Of Cytoskeleton Organization SUMO Conjugating Enzyme Activity Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Chromosome Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification Process Neuron Projection Morphogenesis Homotypic Cell-cell Adhesion Regulation Of Actin Filament Organization Cell Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Nucleotide Binding Regulation Of Norepinephrine Uptake Negative Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Cellular Component Organization	None