NFAT5 and FOXP3

Number of citations: 30 (PubMedID 15790681)
Data Source: HPRD (in vivo)

		NFAT5	FOXP3
Name		nuclear factor of activated T cells 5	forkhead box P3
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding NFAT Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Response To Stress DNA Damage Response Signal Transduction Positive Regulation Of Gene Expression Calcineurin-NFAT Signaling Cascade Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II R-loop Processing Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Cytokine Stimulus Cellular Hyperosmotic Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Negative Regulation Of Transcription By RNA Polymerase II B Cell Homeostasis Negative Regulation Of Cytokine Production Myeloid Cell Homeostasis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment T Cell Mediated Immunity Tolerance Induction Tolerance Induction To Self Antigen T Cell Tolerance Induction Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Tolerance Induction Regulation Of T Cell Anergy Positive Regulation Of T Cell Anergy Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Peripheral T Cell Tolerance Induction T Cell Anergy Chromatin Remodeling DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Negative Regulation Of Cell Population Proliferation Response To Virus Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Transforming Growth Factor Beta1 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Immature T Cell Proliferation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation T Cell Homeostasis CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Activated T Cell Proliferation Alpha-beta T Cell Proliferation Negative Regulation Of Alpha-beta T Cell Proliferation Lymphocyte Proliferation Isotype Switching To IgE Isotypes Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Response To Rapamycin Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		None	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates transcription of genes involved in WNT signaling
Diseases		None	Permanent neonatal diabetes mellitus (PNDM) Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Adult body size ( 32376654 ) Blood osmolality (transformed sodium) ( 28360221 ) Blood urea nitrogen levels ( 31152163 29403010 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Chloride levels ( 29403010 ) Chronic kidney disease ( 29124443 ) Creatinine levels ( 29124443 ) Estimated glomerular filtration rate ( 31015462 30604766 ) Hand grip strength ( 29691431 ) Heel bone mineral density ( 30598549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828 ) Hyperuricemia ( 29124443 ) Intralaminar thalamic nuclei volume ( 34006833 ) Menarche (age at onset) ( 21102462 27182965 25231870 ) Metabolic syndrome ( 31589552 ) Pulse pressure ( 27841878 28135244 ) Self-reported risk-taking behaviour ( 30181555 ) Serum uric acid levels ( 30993211 29124443 ) Sjögren's syndrome ( 28076899 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Sodium levels ( 29403010 ) Triglyceride levels ( 32154731 ) Type 2 diabetes ( 30054458 30297969 ) Urate levels ( 31985003 23263486 )	Vitiligo ( 27723757 )
Interacting Genes		5 interacting genes: ABL1 FOXP3 NFE2L2 TBC1D4 TRIM14	18 interacting genes: EP300 FOSB IKZF4 KAT8 KRTAP3-3 KRTAP6-2 KRTAP8-1 MDM2 NFAT5 NFATC2 NLK PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RUNX1
Entrez ID		10725	50943
HPRD ID		05272	02242
Ensembl ID		ENSG00000102908	ENSG00000049768
Uniprot IDs		O94916	Q9BZS1
PDB IDs		1IMH	3QRF 4WK8
GO Terms Enriched among Interactors		Regulation Of Hematopoietic Stem Cell Differentiation Cellular Response To Fluid Shear Stress B Cell Homeostasis Regulation Of Hematopoietic Progenitor Cell Differentiation Response To Fluid Shear Stress Negative Regulation Of Endothelial Cell Apoptotic Process T Cell Proliferation Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Apoptotic Process Regulation Of Stem Cell Differentiation Alpha-beta T Cell Differentiation Leukocyte Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Interleukin-2 Production Negative Regulation Of DNA Recombination Lymphocyte Homeostasis Protein Localization To Cytoplasmic Microtubule Plus-end B Cell Activation Involved In Immune Response Positive Regulation Of Glutathione Biosynthetic Process Positive Regulation Of Peripheral T Cell Tolerance Induction Transitional One Stage B Cell Differentiation Alpha-beta T Cell Activation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Type II Interferon Production Podocyte Apoptotic Process DN4 Thymocyte Differentiation T Cell Receptor Signaling Pathway Response To Hydrogen Peroxide Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Lymphocyte Proliferation Cellular Response To Reactive Oxygen Species Inflammatory Response Regulation Of Glutathione Biosynthetic Process Aflatoxin Catabolic Process Establishment Of Endothelial Blood-brain Barrier Regulation Of Tolerance Induction Dependent Upon Immune Response CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment Mononuclear Cell Proliferation Lymphocyte Activation Involved In Immune Response Positive Regulation Of Neuron Projection Development Positive Regulation Of RNA Biosynthetic Process T Cell Differentiation Response To Reactive Oxygen Species Microspike Assembly Nicotinate-nucleotide Adenylyltransferase Activity Cell Activation Involved In Immune Response Antigen Receptor-mediated Signaling Pathway B-1 B Cell Homeostasis Negative Regulation Of DNA Metabolic Process	Protein Propionyltransferase Activity DNA-binding Transcription Factor Binding Pre-mRNA Intronic Binding Histone H4 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Acetyltransferase Activity Transcription By RNA Polymerase II Calcineurin-NFAT Signaling Cascade Positive Regulation Of RNA Metabolic Process Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Calcineurin-mediated Signaling Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Hemopoiesis DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via STAT Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Response To Cocaine Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of Gene Expression Cellular Response To Osmotic Stress Transcription Coactivator Binding Transcription Initiation-coupled Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Protein Processing Positive Regulation Of Alpha-beta T Cell Differentiation