CENPF and NUP133

Number of citations: 47 (PubMedID 17363900)
Data Source: HPRD (in vivo, two hybrid)

		CENPF	NUP133
Name		centromere protein F	nucleoporin 133
Structure		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Chromosome Cytosol Membrane Nuclear Pore Outer Ring Nuclear Membrane
	Molecular Function	Chromatin Binding Protein Binding Microtubule Binding Protein Homodimerization Activity Dynein Complex Binding DNA-binding Transcription Factor Binding	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Muscle Organ Development Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Negative Regulation Of DNA-templated Transcription Cell Division Metaphase Chromosome Alignment Kinetochore Assembly DNA Biosynthetic Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery MRNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport Poly(A)+ MRNA Export From Nucleus Neural Tube Development Neurogenesis Paraxial Mesoderm Development Animal Organ Development System Development MRNA Transport Somite Development Nephron Development
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) Lung function (FVC) ( 30061609 ) Response to antineoplastic agents ( 21659360 ) Serum immune biomarker levels ( 32066700 )	Type 2 diabetes ( 32499647 )
Interacting Genes		12 interacting genes: BRAP CDK1 CENPE CHMP2B FNTA FNTB KPNA1 NDEL1 NUP133 SNAP25 SVIL TOP3B	5 interacting genes: CACNA1C CENPF NUP107 NUP98 TCAP
Entrez ID		1063	55746
HPRD ID		02582	06354
Ensembl ID		ENSG00000117724	ENSG00000069248
Uniprot IDs		A0A9L9PXU7 P49454	Q8WUM0
PDB IDs		Not available	1XKS 3CQC 3CQG 3I4R 5A9Q 7PEQ 7R5J 7R5K
GO Terms Enriched among Interactors		Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Microtubule Associated Complex Protein Prenyltransferase Activity Kinetochore Midbody Protein Prenylation Prenyltransferase Activity Acetyltransferase Activator Activity Chromosome Localization Nuclear Pore Nucleus Organization Kinetochore Microtubule Nuclear Localization Sequence Binding Nuclear Envelope Organization Microtubule Cytoskeleton Organization Involved In Mitosis Organelle Fusion Chromosome Organization Chromosome Segregation Cytosol Organelle Organization Pronuclear Fusion Chromosome, Centromeric Region Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Metaphase Chromosome Alignment Peptide Pheromone Maturation Alpha-tubulin Binding Cortisol Dehydrogenase (NADP+) Activity 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Glutamatergic Postsynaptic Density Negative Regulation Of Zinc Ion Transmembrane Import RNA Topoisomerase Activity Nuclear Membrane Organization Organelle Localization Regulation Of Microtubule-based Movement Regulation Of Cellular Localization Mitotic DNA-templated DNA Replication Spindle Cyclin B1-CDK1 Complex Regulation Of Protein Localization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Metaphase Chromosome Alignment CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Hydroxylysine Biosynthetic Process Detoxification Of Zinc Ion	Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Nuclear Pore Organization Kinetochore Nuclear Periphery Pore Complex Assembly Structural Constituent Of Nuclear Pore Nuclear Envelope Chromosome Organization Protein-containing Complex Assembly Animal Organ Development Chromosome Localization Protein-containing Complex Organization RNA Export From Nucleus Nuclear Pore Nucleus Organization Telomere Tethering At Nuclear Periphery Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Z Disc Nuclear Export Import Into Nucleus MRNA Transport Protein Import Into Nucleus Titin-telethonin Complex Titin Z Domain Binding Sarcomerogenesis Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Chromosome, Centromeric Region RNA Transport Skeletal Muscle Myosin Thick Filament Assembly Protein Localization To Nucleus Nuclear Pore Cytoplasmic Filaments Myosin Filament Assembly Muscle Contraction Membrane Depolarization During AV Node Cell Action Potential Immune System Development Nucleobase-containing Compound Transport FATZ Binding Cellular Component Assembly Skeletal Muscle Thin Filament Assembly Muscle System Process Organelle Organization Pronucleus Nuclear Transport Nucleocytoplasmic Transport Detection Of Muscle Stretch