SMC2 and ABCC5

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SMC2	ABCC5
Name		structural maintenance of chromosomes 2	ATP binding cassette subfamily C member 5
Structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Condensed Chromosome Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Extracellular Exosome	Endosome Golgi Apparatus Golgi Lumen Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity	Nucleotide Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Purine Nucleotide Transmembrane Transporter Activity Heme Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity Macromolecule Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity Carbohydrate Derivative Transmembrane Transporter Activity
	Biological Process	Nuclear Division Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Meiotic Chromosome Segregation Chromosome Organization Cell Division Kinetochore Organization Positive Regulation Of Chromosome Segregation Nuclear Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation	Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Purine Nucleotide Transport Hyaluronan Biosynthetic Process Glutathione Transmembrane Transport Heme Transmembrane Transport Xenobiotic Transport Transmembrane Transport CAMP Transport CGMP Transport Monoatomic Anion Transmembrane Transport Folate Transmembrane Transport Export Across Plasma Membrane Transport Across Blood-brain Barrier Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes	Hyaluronan metabolism ABC-family proteins mediated transport Azathioprine ADME Paracetamol ADME
Drugs		None	Curcumin Curcumin sulfate
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Apolipoprotein A1 levels ( 32203549 ) Basal cell carcinoma ( 31174203 33549134 ) HDL cholesterol levels ( 32203549 ) Keratinocyte cancer (MTAG) ( 31174203 ) Oily fish consumption ( 32066663 ) Orofacial clefts (maternal alcohol consumption interaction) ( 21618603 ) Pancreatic cancer ( 29422604 ) Pancreatic ductal adenocarcinoma ( 30541042 ) Pork consumption ( 32066663 ) Sensorimotor dexterity ( 31596458 )	Anterior chamber depth ( 24603532 ) Basophil percentage of white cells ( 32888494 ) Eosinophil count ( 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil count ( 32888494 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 ) Red cell distribution width ( 32888494 ) Type 2 diabetes ( 30297969 ) White blood cell count ( 32888494 )
Interacting Genes		11 interacting genes: ABCC5 CDC42 CEBPA DISC1 DNMT3B GULP1 LIG4 NCAPD2 PTEN SMC4 TRAF3IP1	5 interacting genes: AK2 RBP5 SERPINA3 SMC2 TIAM1
Entrez ID		10592	10057
HPRD ID		09277	06898
Ensembl ID		ENSG00000136824	ENSG00000114770
Uniprot IDs		A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1	O15440
PDB IDs		4U4P	8KCI 8WI2 8WI3 8WI4 8WI5
GO Terms Enriched among Interactors		Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Organelle Organization Dendritic Spine Morphogenesis Response To Lithium Ion Cellular Response To Lithium Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Organization Mitotic Chromosome Condensation Regulation Of Chromosome Condensation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Embryonic Heart Tube Development Phagocytosis, Engulfment Positive Regulation Of Chromosome Segregation Dendritic Spine Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Separation Condensed Chromosome Positive Regulation Of Organelle Organization Response To Electrical Stimulus Chromosome Condensation Positive Regulation Of Proteolysis Neuron Projection Organization Postsynapse Organization System Development Regulation Of Cell-substrate Adhesion Ciliary Base Macrophage Differentiation Membrane Invagination Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Establishment Of Integrated Proviral Latency Regulation Of Chromosome Organization Negative Regulation Of Synaptic Vesicle Clustering Chromosome Organization Involved In Meiotic Cell Cycle Condensed Nuclear Chromosome Carbohydrate Derivative Transmembrane Transporter Activity CGMP Transport Macromolecule Transmembrane Transporter Activity Regulation Of Organelle Organization Regulation Of Cell Cycle Process Mononuclear Cell Differentiation GBD Domain Binding Storage Vacuole Positive Regulation Of Cell Cycle	Extracellular Exosome ADP Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Nucleoside Monophosphate Phosphorylation Sperm Mitochondrial Sheath Nucleobase-containing Compound Kinase Activity Phosphotransferase Activity, Phosphate Group As Acceptor AMP Kinase Activity Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Nucleoside Diphosphate Biosynthetic Process Ribonucleoside Diphosphate Biosynthetic Process Lipid Binding Regulation Of Dopaminergic Neuron Differentiation Meiotic Chromosome Segregation Regulation Of Chromosome Condensation Retinol Binding Retinal Binding Retinoid Binding Mitotic Chromosome Condensation Kinetochore Organization