SORBS1 and PILRA

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SORBS1	PILRA
Name		sorbin and SH3 domain containing 1	paired immunoglobin like type 2 receptor alpha
Structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Membrane Nuclear Matrix Flotillin Complex Cell-substrate Junction Membrane Raft Anchoring Junction	Extracellular Region Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	Protein Binding MHC Class I Protein Binding
	Biological Process	Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Signal Transduction
Pathways		Smooth Muscle Contraction	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525 ) Estimated glomerular filtration rate ( 31152163 ) Hematocrit ( 32888494 ) Mean platelet volume ( 32888494 ) Obesity-related traits ( 23251661 ) PR interval ( 30046033 32439900 ) Red blood cell count ( 32888494 ) Staphylococcus aureus nasal carriage (persistent) ( 26569114 ) Suicide risk ( 21041247 )	Advanced age-related macular degeneration ( 26691988 ) Blood protein levels ( 30072576 ) Brain morphology (MOSTest) ( 32665545 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Red cell distribution width ( 32888494 ) Refractive error ( 32231278 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		31 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN AKT1 CBL CDK6 EFNB1 FLOT1 HUNK INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RNF10 RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC SYNJ1 TENM1 VCL	10 interacting genes: DNPH1 FAM114A2 FCAR PAICS PFDN5 PTPN11 PTPN6 SORBS1 TOM1 UROD
Entrez ID		10580	29992
HPRD ID		05587	05631
Ensembl ID		ENSG00000095637	ENSG00000085514
Uniprot IDs		A0A3B3IRW8 B4DTX5 Q9BX66	Q9UKJ1
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP	3WUZ 3WV0 4NFB 5XO2 5XOF
GO Terms Enriched among Interactors		SH2 Domain Binding Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cell-cell Junction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Protein Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Cellular Response To Fluid Shear Stress Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Cell Motility Kinase Activity Response To Fluid Shear Stress Lamellipodium Response To Growth Factor Regulation Of Locomotion SH3 Domain Binding Vascular Endothelial Cell Response To Fluid Shear Stress Ephrin Receptor Signaling Pathway Regulation Of Cell-substrate Adhesion Cell Migration Developmental Process Protein Autophosphorylation Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of Organelle Organization Regulation Of Protein Phosphorylation Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Focal Adhesion Assembly Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Activation Of Immune Response Cell-substrate Adhesion Regulation Of Phosphorylation Immune System Process Cell Motility Regulation Of Cell-substrate Junction Organization Fc Receptor Mediated Stimulatory Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Modification Process Cell-cell Contact Zone	Neutrophil Activation Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Myeloid Leukocyte Activation Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Insulin Receptor Binding Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Response To Insulin Stimulus Carboxy-lyase Activity Regulation Of Lipopolysaccharide-mediated Signaling Pathway Signaling Receptor Complex Adaptor Activity Positive Regulation Of D-glucose Import Regulation Of Type I Interferon-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of D-glucose Transmembrane Transport Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin IgA Receptor Activity RNA Polymerase III Assembly RNA Polymerase I Assembly Epididymis Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of D-glucose Import Uroporphyrinogen Decarboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Myeloid Cell Development Regulation Of Insulin Receptor Signaling Pathway Nucleoside Monophosphate Metabolic Process Negative Regulation Of T Cell Proliferation Regulation Of D-glucose Transmembrane Transport Regulation Of Cellular Response To Insulin Stimulus Specific Granule Membrane RNA Polymerase II Core Complex Assembly Protein Dephosphorylation Intestinal Epithelial Cell Migration Myosin VI Binding 5-hydroxymethyl-dUMP N-hydrolase Activity Immune Effector Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Adhesion Molecule Binding Protein Tyrosine Phosphatase Activity Negative Regulation Of Leukocyte Proliferation IgA Binding