AKAP3 and SPA17

Number of citations: 35 (PubMedID 15257753)
Data Source: HPRD (in vitro)

		AKAP3	SPA17
Name		A-kinase anchoring protein 3	sperm autoantigenic protein 17
Structure		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Cilium Cytoplasmic Vesicle Motile Cilium Sperm Fibrous Sheath Cell Projection Sperm Midpiece Sperm Principal Piece	Extracellular Region Cytoplasm Cilium External Side Of Plasma Membrane Membrane Motile Cilium Sperm Fibrous Sheath Neuron Projection Sperm Principal Piece
	Molecular Function	Protein Binding Protein Kinase A Binding	Protein Binding Calmodulin Binding
	Biological Process	Blastocyst Hatching Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Single Fertilization Acrosome Reaction Intracellular Protein Localization Flagellated Sperm Motility Establishment Of Protein Localization	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Spermatogenesis Single Fertilization Binding Of Sperm To Zona Pellucida
GWAS		Gut microbiota (bacterial taxa) ( 27723756 )	Bipolar disorder ( 20351715 )
Interacting Genes		8 interacting genes: AKAP4 BRAP GNA13 PRKAR2A ROPN1 ROPN1B ROPN1L SPA17	5 interacting genes: ACTN2 AKAP3 AKAP7 MYL6B ROPN1
Entrez ID		10566	53340
HPRD ID		05256	12272
Ensembl ID		ENSG00000111254	ENSG00000064199
Uniprot IDs		O75969 V9HWD4	A0A172Q397 Q15506
PDB IDs		Not available	8J07
GO Terms Enriched among Interactors		Cilium Movement Motile Cilium Sperm Capacitation Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Microtubule-based Movement Cilium Sperm Fibrous Sheath CAMP-dependent Protein Kinase Complex Microtubule-based Process Developmental Process Involved In Reproduction Cell Maturation Sperm Principal Piece Developmental Maturation Reproductive Process Small GTPase-mediated Signal Transduction Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Cilium Organization Protein Localization To Cilium Rho Protein Signal Transduction Cytoplasm Cell Motility D5 Dopamine Receptor Binding Single Fertilization Male Gamete Generation Spermatogenesis Sperm End Piece Gamete Generation Cell Projection Fertilization Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho-activating G Protein-coupled Receptor Signaling Pathway CAMP-dependent Protein Kinase Regulator Activity Microtubule-based Transport CAMP-dependent Protein Kinase Inhibitor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Nucleotide-activated Protein Kinase Complex Intracellular Signal Transduction Intracellular Signaling Cassette Radial Spoke Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Catalytic Subunit Binding Sperm Head-tail Coupling Apparatus Guanyl Nucleotide Binding Acrosome Reaction Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Sperm Flagellum Assembly	Positive Regulation Of Potassium Ion Transport Protein Kinase A Binding Structural Constituent Of Muscle Titin Z Domain Binding Intracellular Protein Localization Positive Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transport Actin Filament Uncapping Positive Regulation Of Monoatomic Ion Transmembrane Transport Sperm Motility Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Phospholipase C-activating Angiotensin-activated Signaling Pathway Microspike Assembly Positive Regulation Of Monoatomic Ion Transport Cilium Movement FATZ Binding Motile Cilium Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity LIM Domain Binding Sperm Fibrous Sheath Unconventional Myosin Complex Positive Regulation Of Endocytic Recycling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Postsynaptic Actin Cytoskeleton Positive Regulation Of Actin Filament Depolymerization Negative Regulation Of Protein Localization To Cell Surface Cell Projection Titin Binding Regulation Of Metal Ion Transport Actin Filament-based Process Postsynaptic Density, Intracellular Component Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Protein Depolymerization Regulation Of Monoatomic Ion Transport Pseudopodium Microtubule-based Movement Acrosome Reaction Sperm Capacitation Muscle Myosin Complex Actin-myosin Filament Sliding Muscle Filament Sliding Angiotensin-activated Signaling Pathway Regulation Of Endocytic Recycling Postsynaptic Cytoskeleton Organization Regulation Of Membrane Potential Positive Regulation Of Cation Channel Activity