AGPAT2 and GMPS

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		AGPAT2	GMPS
Name		1-acylglycerol-3-phosphate O-acyltransferase 2	guanine monophosphate synthase
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Cytoplasm Cytosol
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Transferase Activity Acyltransferase Activity	Nucleotide Binding GMP Synthase Activity GMP Synthase (glutamine-hydrolyzing) Activity ATP Binding Ligase Activity
	Biological Process	Positive Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Epidermis Development Phospholipid Biosynthetic Process Response To Xenobiotic Stimulus CDP-diacylglycerol Biosynthetic Process Triglyceride Biosynthetic Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process
Pathways		Synthesis of PA Neutrophil degranulation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Purine ribonucleoside monophosphate biosynthesis Azathioprine ADME
Drugs		None	Glutamic acid
Diseases		Congenital generalized lipodystrophy (CGL)	None
GWAS		No GWAS studies recorded	Blood metabolite levels ( 27453504 ) Cardiorespiratory fitness (800m run time) ( 32572135 )
Interacting Genes		6 interacting genes: ABCG8 ANKRD28 GMPS PHF11 PHRF1 SLC23A2	6 interacting genes: AGPAT2 CEBPA FILNC1 RNF26 SUMO4 USP7
Entrez ID		10555	8833
HPRD ID		04373	10927
Ensembl ID		ENSG00000169692	ENSG00000163655
Uniprot IDs		A0A024R8F9 O15120	A0A140VJK6 P49915
PDB IDs		Not available	2VPI 2VXO
GO Terms Enriched among Interactors		GMP Synthase (glutamine-hydrolyzing) Activity GMP Synthase Activity L-ascorbic Acid Transmembrane Transport L-ascorbic Acid Transmembrane Transporter Activity L-ascorbate:sodium Symporter Activity Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Absorption ATP-binding Cassette (ABC) Transporter Complex Purine Nucleobase Biosynthetic Process L-ascorbic Acid Metabolic Process Protein Serine/threonine Phosphatase Complex Intestinal Cholesterol Absorption Regulation Of Intestinal Cholesterol Absorption Regulation Of Intestinal Lipid Absorption Intestinal Lipid Absorption Regulation Of Intestinal Absorption GMP Biosynthetic Process Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Cellular Response To Ethanol Apical Plasma Membrane Positive Regulation Of Dendrite Extension Vitamin Transmembrane Transport RNA Polymerase Binding	None