AGPAT2 and PHF11

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		AGPAT2	PHF11
Name		1-acylglycerol-3-phosphate O-acyltransferase 2	PHD finger protein 11
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Nucleus Nucleoplasm Nuclear Membrane
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Transferase Activity Acyltransferase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Epidermis Development Phospholipid Biosynthetic Process Response To Xenobiotic Stimulus CDP-diacylglycerol Biosynthetic Process Triglyceride Biosynthetic Process	None
Pathways		Synthesis of PA Neutrophil degranulation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	None
Diseases		Congenital generalized lipodystrophy (CGL)	None
GWAS		No GWAS studies recorded	Breastfeeding duration ( 25475840 ) Cardiac hypertrophy ( 21348951 ) Lipoprotein (a) levels ( 30108283 ) Refractive error ( 32231278 )
Interacting Genes		6 interacting genes: ABCG8 ANKRD28 GMPS PHF11 PHRF1 SLC23A2	11 interacting genes: AGPAT2 CSNK2B LSM8 MCPH1 NUTF2 PIAS4 SDCBP SPATC1L TEKT4 TRIM14 TRIM41
Entrez ID		10555	51131
HPRD ID		04373	08480
Ensembl ID		ENSG00000169692	ENSG00000136147
Uniprot IDs		A0A024R8F9 O15120	B4DDL5 Q9UIL8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		GMP Synthase (glutamine-hydrolyzing) Activity GMP Synthase Activity L-ascorbic Acid Transmembrane Transport L-ascorbic Acid Transmembrane Transporter Activity L-ascorbate:sodium Symporter Activity Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Absorption ATP-binding Cassette (ABC) Transporter Complex Purine Nucleobase Biosynthetic Process L-ascorbic Acid Metabolic Process Protein Serine/threonine Phosphatase Complex Intestinal Cholesterol Absorption Regulation Of Intestinal Cholesterol Absorption Regulation Of Intestinal Lipid Absorption Intestinal Lipid Absorption Regulation Of Intestinal Absorption GMP Biosynthetic Process Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Cellular Response To Ethanol Apical Plasma Membrane Positive Regulation Of Dendrite Extension Vitamin Transmembrane Transport RNA Polymerase Binding	Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Identical Protein Binding Regulation Of Cytokine-mediated Signaling Pathway