FST and C8orf33

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		FST	C8orf33
Name		follistatin	chromosome 8 open reading frame 33
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm	None
	Molecular Function	Protein Binding Activin Receptor Antagonist Activity Heparan Sulfate Proteoglycan Binding Activin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Hematopoietic Progenitor Cell Differentiation Gamete Generation Pattern Specification Process Female Gonad Development Cell Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Keratinocyte Proliferation Positive Regulation Of Hair Follicle Development Cellular Response To Growth Factor Stimulus	None
Pathways		Antagonism of Activin by Follistatin	None
Drugs		D-Myo-Inositol-Hexasulphate	None
GWAS		Acne (severe) ( 24927181 30542056 ) Alzheimer's disease (late onset) ( 30820047 ) Central corneal thickness ( 32528159 ) Estimated glomerular filtration rate ( 31152163 ) HDL cholesterol levels ( 32203549 ) Height ( 31562340 ) High-grade serous ovarian cancer ( 31469419 ) Intraocular pressure ( 29235454 29617998 ) Keratoconus ( 33649486 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Midgestational circulating levels of PCBs ( 28235828 ) Optic disc size ( 31809533 ) Refractive error ( 32231278 ) Vaginal microbiome composition (community state type) ( 32723796 )	No GWAS studies recorded
Interacting Genes		14 interacting genes: BEX2 BMP5 C8orf33 CATSPER1 CREB5 FN1 HOXA1 INHA INHBA INHBE MEST TK1 TXN ZNF587	50 interacting genes: AAMP ALAS1 APP BLOC1S2 BRD4 CEP70 CFTR CRELD2 DISC1 DVL3 EDRF1 EPS8 FAM9B FEZ1 FST FYN GIT1 GPRASP1 HAP1 HMBOX1 IKZF1 IMMT KBTBD7 KCTD6 KRTAP10-7 LZTS2 MAPK8IP2 MCC MDFI MRFAP1 NACC1 NGEF NOL7 PI4KA PICK1 PNMA1 RASSF1 SF3B2 TAOK1 TNIP1 TRIM23 TRIM41 TUBA1A TUBB2B WIZ ZC3H15 ZFP28 ZNF205 ZNF331 ZNF526
Entrez ID		10468	65265
HPRD ID		00641	07951
Ensembl ID		ENSG00000134363	ENSG00000182307
Uniprot IDs		P19883	Q9H7E9
PDB IDs		2B0U 2P6A 3HH2 5JHW	Not available
GO Terms Enriched among Interactors		Inhibin A Complex Negative Regulation Of Follicle-stimulating Hormone Secretion Growth Factor Activity Regulation Of Follicle-stimulating Hormone Secretion Hemoglobin Biosynthetic Process Positive Regulation Of Follicle-stimulating Hormone Secretion Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of B Cell Differentiation Negative Regulation Of Gonadotropin Secretion Negative Regulation Of Macrophage Differentiation Cytokine Activity Hemoglobin Metabolic Process Hormone Activity Regulation Of Macrophage Differentiation Signaling Receptor Binding Activin Receptor Signaling Pathway Negative Regulation Of B Cell Activation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Endodermal Cell Differentiation Regulation Of B Cell Differentiation Reproductive Structure Development Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Leukocyte Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Immune System Process Negative Regulation Of Cell Activation Semicircular Canal Formation Inhibin B Complex Ovarian Follicle Development Negative Regulation Of Myeloid Leukocyte Differentiation Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Hormone Secretion Erythrocyte Differentiation Cardiac Fibroblast Cell Development Type II Activin Receptor Binding Positive Regulation Of Ovulation Progesterone Secretion Thymidine Kinase Activity Cellular Detoxification Of Hydrogen Peroxide Negative Regulation Of Multicellular Organismal Process Neural Fold Elevation Formation Negative Regulation Of Monocyte Activation Negative Regulation Of Cytokine Production Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate	Cytoplasm Growth Cone Gamma-tubulin Binding Identical Protein Binding Protein Binding Regulation Of JNK Cascade Modulation Of Chemical Synaptic Transmission Ephrin Receptor Binding Negative Regulation Of Signaling Learning Growth Factor Receptor Binding Regulation Of Cell Communication Nucleus Negative Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Projection Organization Postsynaptic Density Protein-containing Complex Binding Centrosome Regulation Of Cell Projection Organization Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Neuron Projection Organization Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Cellular Component Organization Ephrin Receptor Signaling Pathway Dendritic Spine Maintenance Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Dendritic Spine Maintenance Cytosol Golgi-associated Vesicle Membrane Regulation Of Postsynapse Organization Neuron Cellular Homeostasis Regulation Of Cytoskeleton Organization Neuron Migration Microtubule Cytoskeleton Cell Projection Organization Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Neuron Projection Development Cellular Component Maintenance Regulation Of Microtubule-based Process Learning Or Memory Heparan Sulfate Proteoglycan Binding