COG5 and COG7

Number of citations: 73 (PubMedID 35831314)
Data Source: BioGRID (biochemical), HPRD (in vitro)

		COG5	COG7
Name		component of oligomeric golgi complex 5	component of oligomeric golgi complex 7
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Golgi Transport Complex Trans-Golgi Network Membrane	Golgi Membrane Nucleolus Golgi Apparatus Membrane Golgi Transport Complex Trans-Golgi Network Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Retrograde Transport, Vesicle Recycling Within Golgi Intra-Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Inter-Golgi Cisterna Vesicle-mediated Transport Glycosylation	Retrograde Transport, Vesicle Recycling Within Golgi Protein Glycosylation Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Protein Localization To Organelle Protein Localization To Golgi Apparatus Protein Stabilization Glycosylation
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Diseases		None	Congenital disorders of glycosylation (CDG) type II
GWAS		Apolipoprotein A1 levels ( 32203549 ) Atrial fibrillation ( 29892015 ) Daytime nap ( 33568662 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) HDL cholesterol levels ( 32203549 ) LDL cholesterol ( 30275531 ) Macular thickness ( 30535121 ) Medication use (beta blocking agents) ( 31015401 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 32888494 ) Osteoarthritis ( 20112360 ) Pulse pressure ( 30578418 30224653 ) Serum alkaline phosphatase levels ( 33339817 33547301 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Egg allergy ( 25710614 )
Interacting Genes		5 interacting genes: APC COG4 COG7 MEFV RAC1	8 interacting genes: COG4 COG5 EMILIN1 HNRNPD KIFC3 MEOX2 TAX1BP1 ZNF471
Entrez ID		10466	91949
HPRD ID		08436	07373
Ensembl ID		ENSG00000164597	ENSG00000168434
Uniprot IDs		A0AAA9X096 A0AAA9X2X8 Q9UP83	A0A0S2Z652 P83436
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Lamellipodium Intra-Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Microtubule Polymerization Or Depolymerization Ruffle Membrane Pyroptosome Complex Assembly Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Golgi Organization Trans-Golgi Network Membrane Negative Regulation Of Cellular Component Organization Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Glycosylation Cell-cell Junction Organization Regulation Of Ovarian Follicle Development Erythrocyte Enucleation Regulation Of Cell Projection Assembly Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Auditory Receptor Cell Morphogenesis Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Regulation Of Microtubule-based Process Leading Edge Membrane Wnt Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization To Centrosome Kinocilium Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Interleukin-23 Production G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Neuron Maturation Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Thioesterase Binding Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Vesicle-mediated Transport Golgi Vesicle Transport Wnt Signalosome Positive Regulation Of Pseudopodium Assembly Beta-catenin Destruction Complex	Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Golgi Organization Intra-Golgi Vesicle-mediated Transport Hepatocyte Dedifferentiation Cellular Response To Putrescine