CDX1 and SOX2

Number of citations: 64 (PubMedID 15143193)
Data Source: BioGRID (pull down)

		CDX1	SOX2
Name		caudal type homeobox 1	SRY-box transcription factor 2
Structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding Nitric-oxide Synthase Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Embryonic Pattern Specification Animal Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Regulation Of Somitogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Bone Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Chromatin Organization Regulation Of DNA-templated Transcription Brain Development Response To Wounding Regulation Of Gene Expression Glial Cell Fate Commitment Pituitary Gland Development Adenohypophysis Development Positive Regulation Of Cell-cell Adhesion Neuron Differentiation Forebrain Development Somatic Stem Cell Population Maintenance Tissue Regeneration Positive Regulation Of MAPK Cascade Response To Ethanol Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Response To Growth Factor Cellular Response To Hypoxia Negative Regulation Of Canonical Wnt Signaling Pathway Response To Oxygen-glucose Deprivation Neuronal Stem Cell Population Maintenance Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Myofibroblast Cell Apoptotic Process
Pathways		None	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Deactivation of the beta-catenin transactivating complex Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by MECP2 Germ layer formation at gastrulation Formation of the anterior neural plate Formation of the anterior neural plate Formation of the posterior neural plate Formation of the posterior neural plate Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Diseases		None	Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Distal colorectal cancer ( 33632709 ) Distal/Left-sided colorectal cancer ( 33632709 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Rectal cancer ( 33632709 )	Adult body size ( 32376654 ) Age-related nuclear cataracts ( 33311586 ) Cataracts ( 34127677 ) Cataracts (operation) ( 31816047 ) Chronotype ( 30696823 ) Excessive hairiness ( 29895819 ) Eyebrow thickness ( 30248107 ) General risk tolerance (MTAG) ( 30643258 ) Monobrow ( 27182965 ) Night sleep phenotypes ( 27126917 ) Self-reported risk-taking behaviour ( 30181555 ) Toxoplasma gondii sag1 antibody levels ( 33204752 )
Interacting Genes		3 interacting genes: CEBPA LEF1 SOX2	19 interacting genes: ALX4 CASP8 CDK1 CDX1 FZR1 HNF1B L3MBTL3 MAPK3 NFIC NR5A1 OTUD7B POU2F1 POU5F1 SETD7 SUMO1 TRIM26 UBR5 WWP2 XPO1
Entrez ID		1044	6657
HPRD ID		02849	08921
Ensembl ID		ENSG00000113722	ENSG00000181449
Uniprot IDs		P47902	A0A0U3FYV6 P48431
PDB IDs		5LUX 7Q3O	1O4X 2LE4 6T7B 6T90 6WX7 6WX8 6WX9 6YOV
GO Terms Enriched among Interactors		Transcription Regulator Complex Granulocyte Differentiation Transcription Cis-regulatory Region Binding Gland Development Regulation Of Cell Cycle DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Inner Ear Development Vasculature Development Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Developmental Process CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regeneration Positive Regulation Of Cell Differentiation Response To Vitamin B2 Positive Regulation Of Macromolecule Biosynthetic Process Cell Population Proliferation C/EBP Complex RNA Polymerase II Transcription Regulator Complex Myeloid Leukocyte Differentiation Positive Regulation Of Metanephric Mesenchymal Cell Migration Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Smooth Muscle Cell Chemotaxis Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Process Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Glomerular Mesangial Cell Proliferation Metanephric Glomerular Capillary Formation Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Platelet Activating Factor Receptor Activity Osteoblast Differentiation Regulation Of Myofibroblast Cell Apoptotic Process Sensory Organ Development Trachea Gland Development Negative Regulation Of Apoptotic Process In Bone Marrow Cell Chromatin White Fat Cell Proliferation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Migration Involved In Vasculogenesis Cell Chemotaxis Vascular Endothelial Growth Factor Binding	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Proteolysis DNA Synthesis Involved In Mitotic DNA Replication Protein Modification Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Nucleocytoplasmic Transport Nucleoplasm Thymidine Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of RNA Metabolic Process Protein K11-linked Ubiquitination Protein Polyubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Endodermal Cell Fate Specification Regulation Of Intracellular Protein Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Thymidine Metabolic Process Regulation Of Protein Localization To Nucleus Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Import Into Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Biosynthetic Process