HMG20A and PSORS1C2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HMG20A	PSORS1C2
Name		high mobility group 20A	psoriasis susceptibility 1 candidate 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of Protein Sumoylation Negative Regulation Of Neuron Differentiation	None
GWAS		Fasting glucose ( 34059833 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Glycated hemoglobin levels ( 34059833 ) Hand grip strength ( 29691431 ) Hemoglobin A1c levels ( 29403010 ) Medication use (drugs used in diabetes) ( 31015401 ) Type 2 diabetes ( 21490949 21874001 22693455 22885922 24509480 28869590 30054458 30297969 30718926 32499647 )	Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Broad depression or schizophrenia ( 30626913 ) Clostridioides difficle infection in antibiotics-users ( 33841421 ) Height ( 25282103 28552196 ) Hematology traits ( 23263863 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Malaria ( 31844061 ) Metabolite levels ( 23823483 ) Multiple myeloma ( 26007630 33875642 ) Multiple myeloma and monoclonal gammopathy ( 26007630 ) Night sleep phenotypes ( 27126917 ) Serum uric acid levels ( 30993211 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 21738480 )
Interacting Genes		59 interacting genes: ADD1 AGR2 BACH2 BRAP C9orf72 CCDC136 CCNK CEP95 CFAP53 CREBBP DCTN4 DDIT4L DGCR6L DTNB DYRK1A FBXO7 FMNL1 FOXD4L1 FXR1 GADD45GIP1 GPSM1 GTF2A1L HPCAL1 KIFC3 KPNA2 KRT1 LMO1 LNX1 LURAP1 MAGOHB NTAQ1 NUTF2 OLIG3 PIAS2 PICK1 PSMB1 PSORS1C2 PSTPIP1 PTH2R QARS1 RAD54L2 RBM11 RBM7 RIN1 RPP30 RPRD1B RSPH9 RUSC1 SCNM1 SMAD4 SMYD1 SUOX SYTL4 TBC1D22B TCP11L1 TESC TRAF4 TRAPPC5 USHBP1	27 interacting genes: AGR2 AP1B1 AP2B1 BANP CEP70 ERICH2 EVPL GUCA1C HMG20A HOMER3 LHX3 MED20 MEIS3 MYL2 MYL7 NCKIPSD PAX6 PEX19 REL RTRAF SERTAD1 SGTA SGTB TTC23 UBQLN1 UBQLN2 VASP
Entrez ID		10363	170680
HPRD ID		16116	17921
Ensembl ID		ENSG00000140382	ENSG00000204538
Uniprot IDs		B4DMG1 Q9NP66	A0A1U9X9A6 Q9UIG4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Binding	Positive Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Clathrin Adaptor Complex A Band Cell Fate Specification Protein Targeting Identical Protein Binding ERAD Pathway Response To Endoplasmic Reticulum Stress Heart Contraction Positive Regulation Of Proteasomal Protein Catabolic Process Clathrin Binding Membrane Coat Heart Process Muscle Cell Fate Specification Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity