TLR6 and TLR2

Number of citations: 0 (PubMedID 12077222)
Data Source: HPRD (in vivo)

		TLR6	TLR2
Name		toll like receptor 6	toll like receptor 2
Structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Receptor Complex Membrane Raft	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Receptor Complex Membrane Raft
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Diacyl Lipopeptide Binding Identical Protein Binding Protein Heterodimerization Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding	Lipopolysaccharide Binding Amyloid-beta Binding Lipopolysaccharide Immune Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Identical Protein Binding Peptidoglycan Binding Protein-containing Complex Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Microglial Cell Activation Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Gene Expression Response To Bacterial Lipoprotein Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Diacyl Bacterial Lipopeptide Defense Response To Bacterium Positive Regulation Of Macrophage Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Positive Regulation Of Inflammatory Response Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Toll-like Receptor Signaling Pathway Immune System Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction Learning Positive Regulation Of Gene Expression Microglia Development Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Negative Regulation Of Synapse Assembly Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Type II Interferon Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand RSV-host interactions	ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Modulation by Mtb of host immune system SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions
Drugs		Pam2csk4	Lyme disease vaccine (recombinant OspA) Adapalene S-(Dimethylarsenic)Cysteine Golotimod Tuberculin purified protein derivative Pam2csk4
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Allergic sensitization ( 23817571 30013184 ) Allergy ( 27182965 ) Asthma ( 31959851 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767 ) Helicobacter pylori serologic status ( 23652523 ) Self-reported allergy ( 23817569 )	Body fat mass ( 28552196 )
Interacting Genes		4 interacting genes: BTK HRAS TLR2 TRAP1	29 interacting genes: AKT1 ANP32B CD14 EGFR FBP1 HEMGN HMGB1 HRAS HSP90B1 IRAK1 LY96 MAP2K1 MAPK8IP3 MYD88 NANS PIK3R1 RAC1 RIPK2 SMAD1 STX17 TGFB1 TICAM1 TIRAP TLR1 TLR10 TLR6 TMOD1 TOLLIP TRIP6
Entrez ID		10333	7097
HPRD ID		05656	04323
Ensembl ID		ENSG00000174130	ENSG00000137462
Uniprot IDs		B2R933 Q9Y2C9	A0A0S2Z4S4 B3KWR9 O60603
PDB IDs		4OM7	1FYW 1FYX 1O77 2Z7X 2Z80 6NIG 8AR0
GO Terms Enriched among Interactors		Positive Regulation Of Type I Hypersensitivity Regulation Of Phagocytosis Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Immune Response Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Activation Of Immune Response Toll-like Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway B Cell Affinity Maturation Immune Response-activating Signaling Pathway Glial Cell Development GTPase Complex Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Triacyl Lipopeptide Binding Detection Of Diacyl Bacterial Lipopeptide Translational Attenuation Defense Response To Other Organism Antigen Receptor-mediated Signaling Pathway Regulation Of Interleukin-6 Production Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Regulation Of Intracellular Signal Transduction Phospholipase C Activator Activity Cellular Response To Triacyl Bacterial Lipopeptide Microglia Development Positive Regulation Of Matrix Metallopeptidase Secretion Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Inflammatory Response Innate Immune Response-activating Signaling Pathway Regulation Of Tumor Necrosis Factor Production Cellular Response To Molecule Of Fungal Origin Regulation Of Cytokine Production Detection Of Bacterial Lipoprotein	Regulation Of Innate Immune Response Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Innate Immune Response Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Activation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Molecule Of Bacterial Origin Defense Response Immune Response-activating Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Cytokine Production Regulation Of Defense Response Immune Response-regulating Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Interleukin-6 Production Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Cellular Response To Bacterial Lipopeptide Toll-like Receptor 2 Binding Response To Lipid Response To Bacterial Lipoprotein Positive Regulation Of Gene Expression Innate Immune Response Regulation Of Cytokine Production Response To Stress Response To External Biotic Stimulus Regulation Of Immune System Process Response To Other Organism Defense Response To Symbiont Cellular Response To Lipid Immune Response Regulation Of Interleukin-6 Production Regulation Of Signal Transduction