APC2 and MAPRE1

Number of citations: 0 (PubMedID 10644998)
Data Source: HPRD (in vitro)

		APC2	MAPRE1
Name		APC regulator of Wnt signaling pathway 2	microtubule associated protein RP/EB family member 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Actin Filament Microtubule Cytoskeleton Catenin Complex Midbody Beta-catenin Destruction Complex Leading Edge Membrane Lamellipodium Membrane Filamentous Actin Intercellular Bridge Perinuclear Region Of Cytoplasm Plasma Membrane Bounded Cell Projection	Spindle Pole Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Focal Adhesion Microtubule Cytoskeleton Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end Ciliary Basal Body Cell Projection Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Astral Microtubule End Mitotic Spindle Microtubule
	Molecular Function	Protein Binding Beta-catenin Binding Microtubule Binding Gamma-catenin Binding	RNA Binding Protein Binding Microtubule Binding Identical Protein Binding Cadherin Binding Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding
	Biological Process	Microtubule Cytoskeleton Organization Cell Fate Specification Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Nervous System Development Wnt Signaling Pathway Cell Migration Negative Regulation Of Wnt Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Activation Of GTPase Activity	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Intracellular Protein Localization Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Protein Localization To Microtubule Microtubule Polymerization Spindle Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Centrosome Protein Localization To Mitotic Spindle Protein Localization To Astral Microtubule Non-motile Cilium Assembly
Pathways		None	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Diseases		Colorectal cancer	None
GWAS		Lean body mass ( 28552196 )	Brain morphology (MOSTest) ( 32665545 ) Mean platelet volume ( 32888494 ) Oily fish consumption ( 32066663 ) Polycystic ovary syndrome ( 30566500 ) Pork consumption ( 32066663 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Interacting Genes		9 interacting genes: AXIN2 CTNNB1 DSCAM FXR1 MAPRE1 MAPRE3 NLGN3 SMARCA2 YAP1	50 interacting genes: ABCB1 APC APC2 APP AURKB BCL3 C20orf202 CASK CCSER1 CDC42 CDK5RAP2 CLASP1 CLASP2 COPS5 COPS8 CSN3 CYLD DCTN1 GTSE1 HSPA1A IKBKG KAT2B KAT5 KLHL12 KLHL21 KNSTRN LMO2 LRP1 MACF1 MARCHF7 MEOX2 NAV1 NUPR1 PAX6 PIK3R4 POLE2 PQBP1 PRPF3 PSMA1 SLAIN1 SPDYE2 SPDYE2B SRC SRPK2 STK11 TERF1 TRAF2 TUBA1A TUBB ZNF653
Entrez ID		10297	22919
HPRD ID		09802	04379
Ensembl ID		ENSG00000115266	ENSG00000101367
Uniprot IDs		O95996	Q15691
PDB IDs		Not available	1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3MTU 3MUD 3TQ7 4XA1 4XA3 4XA6 5JV3 5JVM 5JVP 5JVR 5JVS 5JVU 5JX1 5WLQ 6PF2 6PFP 6YF5 6YSH
GO Terms Enriched among Interactors		Regulation Of Cell Development Regulation Of Multicellular Organismal Development Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Nervous System Development Regulation Of Cellular Component Organization Positive Regulation Of Nervous System Development Positive Regulation Of Multicellular Organismal Process Regulation Of Organelle Organization Regulation Of Neurogenesis Mitotic Spindle Astral Microtubule End Positive Regulation Of Cell Development Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Cell Differentiation Regulation Of Developmental Process Positive Regulation Of Neurogenesis Regulation Of Microtubule Polymerization Neuron To Neuron Synapse Beta-catenin Destruction Complex Regulation Of Nephron Tubule Epithelial Cell Differentiation Cell Projection Membrane Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Microtubule Polymerization Or Depolymerization Dorsal/ventral Axis Specification Negative Regulation Of Microtubule Polymerization Protein Localization To Microtubule Regulation Of Epithelial Cell Differentiation Involved In Kidney Development I-SMAD Binding Regulation Of Sister Chromatid Cohesion Developmental Growth Involved In Morphogenesis Microtubule Plus-end Binding Cell Development Regulation Of Osteoblast Differentiation Protein Serine/threonine Kinase Binding Cellular Component Assembly Microtubule Plus-end Glandular Epithelial Cell Differentiation Regulation Of Microtubule Cytoskeleton Organization Spindle Midzone Lung Epithelial Cell Differentiation Lung Cell Differentiation Germ Cell Development Positive Regulation Of Cellular Component Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Chromosome Organization Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Synapse Organization Positive Regulation Of Stem Cell Population Maintenance	Regulation Of Microtubule-based Process Cytoskeleton Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Cytoskeleton Organization Regulation Of Cell Cycle Microtubule-based Process Establishment Of Mitotic Spindle Localization Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Cytoplasm Microtubule Cytoskeleton Regulation Of Organelle Organization Establishment Of Organelle Localization Organelle Localization Mitotic Spindle Microtubule Plus-end Positive Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Establishment Of Spindle Localization Kinetochore Spindle Localization Centrosome Positive Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Microtubule Binding Cellular Component Assembly Regulation Of Microtubule Depolymerization Microtubule Cytoskeleton Organization Involved In Mitosis Cytosol Establishment Of Localization In Cell Establishment Of Spindle Orientation Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Metabolic Process Microtubule Plus-end Binding Spindle Perinuclear Region Of Cytoplasm Protein Kinase Binding Negative Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cytoskeleton Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Macromolecule Metabolic Process