EFS and NUP155

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		EFS	NUP155
Name		embryonal Fyn-associated substrate	nucleoporin 155
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Focal Adhesion	Nucleus Nuclear Envelope Nuclear Pore Cytosol Membrane Nuclear Membrane Nuclear Pore Inner Ring
	Molecular Function	Protein Binding SH3 Domain Binding Protein Domain Specific Binding	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Intracellular Signal Transduction	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Envelope Organization Protein Transport Protein Localization To Nucleus MiRNA Processing Protein Localization To Nuclear Inner Membrane MRNA Transport Atrial Cardiac Muscle Cell Action Potential
Pathways		None	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
GWAS		No GWAS studies recorded	Malaria ( 31844061 ) Meat-related diet ( 32066663 )
Interacting Genes		36 interacting genes: ABI2 AGXT APP BCAR1 BDKRB2 BLK CCDC187 CRK FYN GLMN GPANK1 LHX8 LYST MYOZ3 NCK1 NCK2 NF1 NLGN3 NPAS2 NUP155 OSTF1 PIN1 PTK2 PTK2B PTPN12 SH2D3C SH3RF2 SORBS2 SORBS3 SRC TRAPPC6A TSSK1B UBASH3B UBC YES1 ZNF417	7 interacting genes: CDC42 EFS GLE1 NUP35 PDCD6IP UBC ZFYVE9
Entrez ID		10278	9631
HPRD ID		09932	05984
Ensembl ID		ENSG00000100842	ENSG00000113569
Uniprot IDs		O43281	B4DLT2 E9PF10 O75694
PDB IDs		Not available	5A9Q 5IJN 5IJO 7EYE 7EYF 7EYQ 7PER 7R1Y 7R5J 7R5K
GO Terms Enriched among Interactors		Signal Complex Assembly Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Anchoring Junction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoskeletal Anchor Activity Cell Migration Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Scaffold Protein Binding Signaling Receptor Activator Activity Regulation Of Cell Adhesion ERBB Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Motility Signaling Receptor Binding Positive Regulation Of Supramolecular Fiber Organization Regulation Of Immune System Process Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Intrinsic Apoptotic Signaling Pathway Phosphotyrosine Residue Binding SH3 Domain Binding Response To Growth Factor Signal Transduction Positive Regulation Of Immune System Process Regulation Of Cell Motility Fc Receptor Signaling Pathway Regulation Of MAPK Cascade Protein Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Locomotion Immune Response-activating Signaling Pathway Leukocyte Migration Regulation Of Cell-cell Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Postsynapse Organization Positive Regulation Of Signal Transduction Negative Regulation Of Immune System Process Phosphorylation	Apolipoprotein A-I Receptor Binding Cellular Localization Endothelin Receptor Signaling Pathway Involved In Heart Process Focal Adhesion Establishment Or Maintenance Of Apical/basal Cell Polarity Centrosome Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Establishment Of Localization In Cell Intracellular Transport Establishment Or Maintenance Of Cell Polarity RNA Transport Inositol Hexakisphosphate Binding Nuclear Pore Cytoplasmic Filaments Phospholipid Binding MRNA Transport Nuclear Pore Extracellular Vesicle Biogenesis Extracellular Exosome Biogenesis Nucleus Organization Positive Regulation Of Extracellular Exosome Assembly Proteinase Activated Receptor Binding Actomyosin Contractile Ring Assembly Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cell-cell Junction Organization Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Extracellular Exosome Assembly Nuclear Pore Central Transport Channel Intracellular Protein Localization Nucleobase-containing Compound Transport Nuclear Envelope Establishment Of Golgi Localization Protein Domain Specific Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Leading Edge Membrane Thioesterase Binding Neuron Fate Determination Golgi Transport Complex Actomyosin Nuclear Transport Nucleocytoplasmic Transport Endothelin Receptor Signaling Pathway Cell Junction Assembly Cytosol